Host:Rabbit
Target Protein:BLM
IR:Immunogen Range:761-860/1417
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:641
Swiss Prot:P54132
Source:KLH conjugated synthetic peptide derived from human BLM:761-860/1417
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Bloom’s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom’s syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom’s syndrome patients. One characteristic of Bloom’s syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom’s cells.
Size:50ul
Concentration:1mg/ml
Applications:IHC-P(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Pig
Horse
Rabbit
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用！
关键字： RECQ2;RECQL2;RECQL 2;RECQL3;MGC126616;
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