Rabbit Anti-MLCK Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:MLCK
IR:Immunogen Range:651-750/1914
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:4638
Swiss Prot:Q15746
Source:KLH conjugated synthetic peptide derived from human MLCK:651-750/1914
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq].
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1ug/Test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Sheep
Guinea Pig
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： MLCK;osin light chain kin;DKFZp686I10125;EC 2.7.11.18;FLJ12216;Kinase related prote;KRP;MLCK1;
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