Rabbit Anti-PYK2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:PYK2
IR:Immunogen Range:31-130/1009
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2185
Swiss Prot:Q14289
Source:KLH conjugated synthetic peptide derived from human FAK2/Pyk2:31-130/1009
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Horse
Rabbit
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: PYK2;CADTK;CAK beta;CAKB antibody;CAKbeta; Calcium dependent t;FAK1;FAK2_HUMAN;
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