Rabbit Anti-Fbx32 Monoclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Fbx32
IR:Immunogen Range:1-200/355
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:114907
Swiss Prot:Q969P5
Source:Recombinant human Fbx32:1-200/355
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Background:Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-1000)
ICC(1:50-200)
Cross Reactive Species:Human
Mouse
Rat
"仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： Fbx32;4833442G10Rik;AI430017;ATROGIN1;Atrophy gene 1;F box only protein 3;FBXO32;FBX32_HUMAN;
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