中文名：伊福地平
英文名：Efonidipine
纯度：Moligand™，≥99%
货号：E413204
Cas号：111011-63-3
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
Efonidipine Efonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.
Targets
T-type calcium channel
In vitro
Although efonidipine is not a specific T-type calcium channe (TTCC) blocker as it could also block L-type calcium channe (LTCC), its efficacy in blocking TTCC is much greater than that of LTCC. Efonidipine exerts an inhibitory effect on aldosterone synthesis and secretion in a human adrenocortical cell line (H295R), an effect that is mediated, at least in part, by suppression of 11-β-hydroxylase and aldosterone synthase expression. Efonidipine also suppresses both Ang II- and K+-induced aldosterone secretion, but it blocks the latter at much lower concentrations than the former.
In vivo
Efonidipine could provide broader beneficial effects including the heart, liver, and plasma, and antioxidant in iron-overload condition in both WT(muβ+⁄+) and HT(muβth-3 ⁄+,) mice.
Cell Research(from reference)
Cell lines：The NCI-H295R human adrenocortical cell line (H295)
Concentrations：0.3 μM and 3 μM
Incubation Time：24 h
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关键字： (+/-)-EFONIDIPINE ; 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2$l^{5}-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ; NCGC00182046-01 ; 1-tert-butoxycarbonyl-piperidine-4-carboxaldehyde
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