中文名：CCT196969
英文名：CCT196969
纯度：Moligand™，≥98%
货号：C413825
Cas号：1163719-56-9
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
CCT196969 is a novel orally available, pan-RAFinhibitor with anti-SRCactivity. It also inhibits SRC, LCK, and the p38 MAPKs.
Targets
CRAF (Cell-free assay); LCK (Cell-free assay); Src (Cell-free assay); V600E-BRAF (Cell-free assay); BRAF (Cell-free assay) ;0.01 μM; 0.02 μM; 0.03 μM; 0.04 μM; 0.1 μM
In vitro
CCT196969 is active against melanoma and colorectal cancer cell lines that are mutant for BRAF, but not cancer cells that are wild-type for BRAF and NRAS. CCT196969 induces caspase 3 and PARP cleavage, thus induces apoptosis. CCT196969 does not drive paradoxical pathway activation and inhibit MEK/ERK in BRAF and NRAS mutant melanoma.
In vivo
CCT196969 is extremely well tolerated at the doses assessed and does not produce any significant adverse effects in vivo. Oral dosing at 10 mg/kg/day of CCT196969 results in plasma concentrations ∼1 μM at 24 hr. It is orally bioavailable at ∼55%.
Cell Research(from reference)
Cell lines：cell line derived from a vemurafenib-resistant melanoma
Concentrations：1 μM
Incubation Time：4 h
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/C413825.html
关键字： Urea,N-?[4-?[(3,?4-?dihydro-?3-?oxopyrido[2,?3-?b]?pyrazin-?8-?yl)?oxy]?-?2-?fluorophenyl]?-?N'-?[3-?(1,?1-?dimethylethyl)?-?1-?phenyl-?1H-?pyrazol-?5-?yl]?-
上海阿拉丁生化科技股份有限公司是A股上市公司（（股票代码：688179），专注于科研试剂的研发、生产和销售，已陆续建立多个工厂和研发中心。作为领军企业，阿拉丁始终坚持质量第一，连续13年被评为“最受欢迎试剂品牌”。
阿拉丁目前常备库存试剂产品品种超过7万种，SKU总数超过46万，产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域，是国内少数化学试剂到生物试剂全面发展的国产试剂品牌，产品同步发布在我们国内外电商平台。