aladdin 阿拉丁 C413566 Ciforadenant?(CPI-444) 1202402-40-1 99%

中文名：Ciforadenant (CPI-444)

英文名：Ciforadenant (CPI-444)

纯度：Moligand™，≥99%

货号：C413566

Cas号：1202402-40-1

存储温度：-20°C储存,充氩

运输条件：超低温运输

产品介绍：

Information

Ciforadenant (CPI-444) Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes.

Targets

A2AR 3.54 nM(Ki)

In vitro

CPI-444 restores T-cell activation in vitro.

In vivo

CPI-444 treatment resulted in a similar inhibition of tumor growth in the B16F10 melanoma (100 mg/kg) and RENCA renal cell cancer syngeneic models (10 mg/kg). It enhances T-cell activation in both the periphery and tumor microenvironment.

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