中文名：Tenovin-1
英文名：Tenovin-1
英文别名：Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
纯度：10mM in DMSO
货号：T408399
包装：1ml
Cas号：380315-80-0
存储温度：-80℃储存
产品介绍：
Information
Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2 . Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH
In vitro
Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.
In vivo
Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.
Cell Data
cell lines：Raw 264.7 cells
Concentrations：10 μM
Incubation Time：4 days
Powder Purity:≥99%
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关键字： Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
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