aladdin 阿拉丁 M129577 ML133 盐酸盐 1222781-70-5 ≥98%

中文名：ML133 盐酸盐

英文名：ML133 HCl

中文别名：(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐

英文别名：1222781-70-5|ML133 HCL|(4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride|ML133 hydrochloride|ML 133 hydrochloride|N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride|ML133 (hydrochloride)|(4-Methoxybenzyl)(1-naphthylmethyl)amine HCl|(4-m

纯度：≥98%

货号：M129577

包装：10mg、50mg、5mg

Cas号：1222781-70-5

存储温度：2-8°C储存

产品介绍：

ML133 HCl是一种选择性钾离子通道抑制剂，作用于Kir2.1， IC50为1.8 μM (pH 7.4)和290 nM (pH 8.5)，对Kir1.1没有作用效果，对Kir4.1和Kir7.1具有微弱的作用活性。ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.

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