Human SDF-1 / CXCL12 Protein, His Tag
分子别名(Synonym)
SDF-1,CXCL12,hSDF-1,IRH,hIRH,PBSF,SDF1,SDF1A,SDF1B
表达区间及表达系统(Source)
Human SDF-1, His Tag (SD1-H5143) is expressed from E. coli cells. It contains AA Lys 22 - Lys 89 (Accession # P48061-2).
Predicted N-terminus: Met
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 10.0 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
通过LYN激酶作为单核细胞迁移的正调节因子和单核细胞粘附的负调节因子。通过其受体CXCR4和ACKR3刺激单核细胞和T淋巴细胞的迁移,并减少单核细胞对ICAM-1(β-2整合素的配体)表面的粘附。SDF1A/CXCR4信号轴通过LYN激酶抑制β-2整合素LFA-1介导的单核细胞与ICAM-1的粘附。抑制由T细胞系适应的HIV-1介导的CXCR4感染。在心肌梗死后起保护作用。诱导各种细胞中表达的ACKR3的下调和内化。在胚胎发育过程中具有几个关键功能;B细胞淋巴细胞生成、骨髓中的骨髓生成和心室间隔形成所必需的。在IL7存在的情况下刺激骨髓源性B细胞祖细胞的增殖以及基质细胞依赖性前B细胞的生长。
关键字: SDF-1;SDF-1蛋白;SDF-1重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。