网站主页 > 化工产品目录 > 生物化工 > 抑制剂 > 丝裂原活化蛋白激酶(MAPK) > MEK 抑制剂 > 5-[(4-溴-2-氟苯基)氨基]-4-氟-N-(2-羟基乙氧基)-1-甲基-1H-苯并咪唑-6-甲酰胺 > MEK162(ARRY-438162; ARRY-162)

MEK162(ARRY-438162; ARRY-162)

MEK162(ARRY-438162; ARRY-162),MEK162(ARRY-438162; ARRY-162)
  • 产品价格:¥714
  • 中文名称:MEK162(ARRY-438162; ARRY-162)
  • 英文名称:MEK162(ARRY-438162; ARRY-162)
  • CAS:606143-89-9
  • 发布时间:2017/6/12 15:14:13
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  • 会员等级: 非企业会员 | 龙岗区布吉街道荣华路中加名园14号楼1号201
  • 产品描述
  • 公司简介

产品属性:

  • 产品名称: MEK162(ARRY-438162; ARRY-162)
  • 产品英文名称: MEK162(ARRY-438162; ARRY-162)
  • 有效期: 一年
发布时间: 2017/6/12 15:14:13 产品名称: MEK162(ARRY-438162; ARRY-162) 产品英文名称: MEK162(ARRY-438162; ARRY-162)
CAS号: 产品包装: RMB 产品价格: 714RMB
有效期: 一年 品牌: 产地:
保存条件: 纯度规格: 产品类别:
441.23
参考CoA中推荐的条件进行储存。
C17H15BrF2N4O3
606143-89-9
in DMSO > 10 mM

 

相关文献

 

[1]. J Pheneger, et al. 2006, ACR Annual Scientific Meeting. Abst 794.

[2]. D Wright, et al. 2009, Arraybiopharma. Abstract FRI0063.

[3]. SS Bhagwat, et al. Annu Rep Med Chem, 2007, 42, 265–278.

[4]. Serra V, et al. RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. J Clin Invest, 2013, 123(6), 2551-2563.

产品描述:

MEK162的生物活性

 

MEK162(ARRY-438162; ARRY-162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM.
IC50 value: 12 nM [1]
Target: MEK1/2
in vitro: ARRY-438162 (625 nM) inhibits in vitro osteoclast differentiation with IC50 of 39 nM. ARRY-438162 (10 μM) inhibits in vitro osteoclast resorption with IC50 of 625 nM. ARRY-438162 (2 μM) weakly affects osteoblast differentiation. [2] ARRY-438162 is a recently disclosed potent and selective ATP non-competitive MEK1/2 inhibitor, inhibits pERK in cells with an IC50 of11 nM. [3] MEK162 (1 μM) combined with MK-2206 (2 μM) completely reverses the resistance of RSK-expressing MCF7 cells. [4]
in vivo: ARRY-438162 (10 mg/kg, po, bid) reduces disease severity in a dose-related manner in rat collagen-induced arthritis (CIA) and rat adjuvant-induced arthritis (AIA) models. ARRY-438162 (po, bid) inhibits increases in ankle diameter by 27% and 50% at 1 mg/kg and 3 mg/kg in the rat collagen-induced arthritis (CIA) model, while ibuprofen has 46% inhibition. ARRY-438162 (10 mg/kg, po, bid) significantly inhibits lesions (inflammation, cartilage damage, pannus formation and bone resorption) by 32% and 60% at 1 mg/kg and 3 mg/kg in the rat collagen-induced arthritis (CIA) model. ARRY-438162 inhibits AIA ankle diameter 11% and 34% at 3 mg/kg and 10 mg/kg in rat adjuvant-induced arthritis (AIA) models [1]. MEK162 (6 mg/kg, BID) combined with BEZ235 results in a significant reduction of tumor growth in immunodeficient mice injected with MCF7 cells [4].

 

化学信息

分子量 储存条件 分子式 CAS号 溶剂/溶解度
关键字:

供应商联系方式:

  • 联系人: 谢小姐
  • 公司名称: 深圳市浩博世纪生物有限公司
  • 电话:0755-29573896
  • 手机: 15994704873
  • 传真 :
  • 邮箱 :2757443387@qq.com
  • 地址 : 龙岗区布吉街道荣华路中加名园14号楼1号201

公司简介:

深圳市浩博世纪生物有限公司位于深圳市龙岗区,是一家专业从事科研用生化试剂及相关产品销售的公司; 产品涉及生化试剂、化学试剂、抗体、对照标准品、ELISA试剂盒、细胞培养试剂、常用耗材及小仪器等;致力于为生物企业、科研院所、大专院校等提供全方位的科研实验服务。 公司与国内外知名企业,科研院校和多家代理商建立了良好的合作关系,是国内产品系列多,品种全,质量优的生物产品和生化试剂供应商。能够满足各生物企业、科研院所、医疗机构的各种需求,能长期提供一站式试剂供应服务。

其他供应商提供的同类产品:

比尼替尼_山东轩鸿生物医药有限公司[2019/08/14] MEK162_ChemScene, LLC[2012/12/11]
MEK162(ARRY-438162; ARRY-162)_深圳市浩博世纪生物有限公司[2017/06/12]


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