Mouse IL-17A / CTLA-8 Protein, His Tag (MALS verified)
分子别名(Synonym)
IL-17A,Interleukin-17A,CTLA-8,IL-17
表达区间及表达系统(Source)
Mouse IL-17A, His Tag (CT8-M5240) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Ala 158 (Accession # Q62386-1).
Predicted N-terminus: His
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 15.8 kDa. The protein migrates as 18 kDa, 20-23 kDa, 26 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.


背景(Background)
白细胞介素-17A(IL17A)也被称为细胞毒性T淋巴细胞相关抗原8(CTLA8),这是一种由活化的T细胞产生的促炎细胞因子。IL17A可以调节NF-κB和丝裂原活化蛋白激酶的活性。此外,IL17A可以刺激IL6和环氧化酶-2(PTGS2/COX-2)的表达,并增强一氧化氮(NO)的产生。此外,IL17A既有糖基化的形式,也有非糖基化形式。高水平的IL-17与几种慢性炎症性疾病有关,包括类风湿性关节炎、银屑病和多发性硬化症。
关键字: IL-17A;IL-17A蛋白;IL-17A重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。