琥珀酸美托洛尔 中文名称：琥珀酸美托洛尔；1-异丙氨基-3-[对-(2-甲氧乙基)苯氧基]-2-丙醇琥珀酸盐 英文名称：Metroprolol succinate CAS号：98418-47-4 分子式：C34H56N2O10 分子量：652.8158 含量：99% 外观：白色结晶性粉末 用途：用于心绞痛，高血压治疗的原料药。美托洛尔是一种选择性β1受体阻滞剂，是治疗高血压、冠心病 慢性心力衰竭和心律失常的常用药物之一 包装：按客户要求 美托洛尔介绍： 上世纪70年代开发的心脏选择性β1受体阻断剂,用于治疗高血压、心绞痛、心肌梗塞、肥厚性心肌病等疾病,是目前临床常用药物。市场上流通的主要是酒石酸美托洛尔缓释片和琥珀酸美托洛尔缓释片,而琥珀酸美托洛尔的溶解度较低而成为缓释片研究热点。 相关产品：酒石酸美托洛尔，琥珀酸美托洛尔缓释片
Items
Specifications
Results
Appearance
White crystalline powder
Conforms
Solubility
Freely soluble in water, soluble in methanol,sparingly soluble in alcohol,slightly soluble in isopropyl alcohol
Clarity and color of solution
Clarity
Not less clear than water
Absorbance
≤0.1
0.03
PH
7.0-7.6
7.23
Identification，IR
Exhibits maxima as that of reference standard
Loss on drying
Not more than 0.2%
0.04%
Residue on ignition
Not more than 0.1%
0.05%
Heavy metals
Not more than 10ppm
Related substance(TLC)
Individual Impurity :Not more than 0.2%
N/D
Related substance (HPLC)
Individual A: Not more than 0.1% Individual B: Not more than 0.1% Individual C: Not more than 0.1% Individual D: Not more than 0.1% Any individual unspecified impurity: Not more than 0.1% Total Impurity: Not more than 0.3%
＜0.1% N/D ＜0.1% N/D RRT0.48:0.06% 0.09%
Residual solvents, GC
Toluene ≤100ppm
0.1ppm
Ethanol ≤1000ppm
330.1ppm
Assay (HPLC)
98.0%-102.0%
100.5%
Content of succinic ion by titration (on dried basis)
17.7%-18.5%
18.06%
Conclusion: The Results Conforms To the Standard Of USP34 Storage ：Store in cool and dry place Store in well-closed containers
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