Human IL-13 R alpha 1 Protein, His Tag (MALS & SPR verified)
分子别名(Synonym)
IL13RA1,CD213A1,IL-13Ra,NR4,RP13-128O4.2,IL13Rα1
表达区间及表达系统(Source)
Human IL-13 R alpha 1 Protein, His Tag (IL1-H5224) is expressed from human 293 cells (HEK293). It contains AA Gly 22 - Thr 343 (Accession # NP_001551.1).
Predicted N-terminus: Gly 22
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 37.7 kDa. The protein migrates as 45-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
白细胞介素13受体α1也被称为IL13RA1、NR4和CD213A1(分化簇213A1)。IL13 Rα1 cDNA编码一个427个氨基酸(aa)残基的前体蛋白,具有一个推定的21个氨基酸残基信号肽、一个324个氨基酸残基胞外结构域、一个23个氨基酸残基数的跨膜区和一个59个氨基酸残数的细胞质尾部。人和小鼠IL13Rα1具有76%的氨基酸序列同一性。IL13RA1是白细胞介素13受体的一个亚基。该亚基与IL13和IL4受体共享的IL4受体α形成受体复合物。该亚基作为IL13受体的主要IL13结合亚基,也可能是IL4受体的组成部分。该蛋白已被证明与酪氨酸激酶TYK2结合,因此可能介导导致IL13和IL4诱导的JAK1、STAT3和STAT6激活的信号传导过程。
关键字: IL13RA1;IL13RA1蛋白;IL-13 R alpha 1;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。