NGFR产品信息
英文名称:Low affinity neurotrophin receptor p75NTR
中文名称:低亲和力神经营养因子受体p75NTR
靶点别称:NGFR,TNFRSF16
物种:Human
标签:Fc Tag
属性:Protein,Cell
标记:Unconjugated
表达区间及表达系统(Source)
Human NGFR Protein, Fc Tag (NGR-H5254) is expressed from human 293 cells (HEK293). It contains AA Lys 29 - Asn 250 (Accession # P08138-1).
Predicted N-terminus: Lys 29
蛋白结构(Molecular Characterization)

This protein carries a human IgG1 Fc tag at the C-terminus
The protein has a calculated MW of 50.0 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
p75神经营养因子受体(p75NTR)最初被鉴定为神经营养因子(NGF R)的低亲和力受体。神经营养因子受体结合神经营养因子,包括神经生长因子、神经营养因子-3、脑源性神经营养因子和神经营养因子-4。所有神经营养因子都与p75NTR结合。这也包括未成熟的促神经营养因子形式。神经营养因子受体,包括p75NTR,负责确保发育中神经元的适当密度与靶比,将发育中更广泛的图谱细化为精确的连接。p75NTR参与促进神经元存活和神经元死亡的途径。
关键字: NGFR;NGFR蛋白;TNFRSF16;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。