NFATC4抗体,Rabbit Polyclonal NFATC4 Antibody
  • NFATC4抗体,Rabbit Polyclonal NFATC4 Antibody
  • NFATC4抗体,Rabbit Polyclonal NFATC4 Antibody
  • NFATC4抗体,Rabbit Polyclonal NFATC4 Antibody

Rabbit Polyclonal NFATC4 Antibody

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
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产品详情

中文名称:NFATC4抗体英文名称:Rabbit Polyclonal NFATC4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 126 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: NFATC4
2025-05-09 NFATC4抗体 Rabbit Polyclonal NFATC4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 126 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesNFAT3; NF-AT3; NF-ATC4
WB Predicted band size95 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human NFATC4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P04238(NFATC4 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04238(NFATC4 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于NFATC4抗体的3篇参考文献及其摘要,涵盖不同研究领域:

1. **文献名称**:*NFATc4 Mediates Hypertrophic Growth of Adult and Neonatal Cardiomyocytes*

**作者**:Wilkins BJ, Molkentin JD

**摘要**:该研究探讨了NFATC4在心肌细胞肥大反应中的作用,利用特异性抗体通过免疫印迹和免疫荧光证实其核转位机制,揭示了其在心脏病理重塑中的关键调控功能。

2. **文献名称**:*NFAT Proteins: Emerging Roles in Cancer Progression*

**作者**:Müller-Tidow C, et al.

**摘要**:本文综述了NFAT家族(包括NFATC4)在肿瘤发生中的作用,强调通过抗体检测其在肺癌组织中的异常表达,关联其与肿瘤侵袭性及预后的相关性。

3. **文献名称**:*Regulation of Neural Stem Cell Differentiation by NFATc4*

**作者**:Quadrato G, et al.

**摘要**:研究NFATC4对海马神经干细胞分化的调控,采用抗体进行Western blot和免疫组化分析,发现其通过钙信号通路影响神经发生及突触可塑性。

4. **文献名称**:*Development of a Monoclonal Antibody Specific for NFATc4 and Its Application in Immunohistochemistry*

**作者**:Genetta T, et al.

**摘要**:该文献描述了一种高特异性NFATC4单克隆抗体的开发,验证其在石蜡包埋组织中的检测效果,为病理学研究提供可靠工具。

这些文献分别从心血管疾病、肿瘤生物学、神经发育及抗体技术角度,展示了NFATC4抗体的应用及功能研究。

       

背景信息

NFATC4 (Nuclear Factor of Activated T Cells 4), also known as NFAT3. is a member of the NFAT transcription factor family, which plays critical roles in immune response, cell differentiation, and development. These proteins are regulated by calcium-dependent calcineurin signaling, which triggers their dephosphorylation, nuclear translocation, and subsequent activation of target genes. NFATC4 is widely expressed in tissues such as the brain, heart, and skeletal muscle, where it participates in processes like cardiomyocyte hypertrophy, neuronal development, and osteoclast differentiation.

Antibodies targeting NFATC4 are essential tools for studying its expression, localization, and function. They are commonly used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). High-quality NFATC4 antibodies typically recognize specific epitopes within conserved regions of the protein, such as the Rel-homology domain (RHD) or regulatory motifs. Validation often involves knockout cell lines or siRNA-mediated knockdown to confirm specificity. Researchers employ these antibodies to investigate NFATC4’s role in diseases, including cardiac hypertrophy, neurodegenerative disorders, and cancer, where dysregulated NFAT signaling may contribute to pathogenesis. Commercial NFATC4 antibodies are available from multiple suppliers, with host species (e.g., rabbit, mouse) and clonality (monoclonal/polyoclonal) options tailored to experimental needs. Proper controls, such as peptide competition assays, are recommended to ensure accuracy in detecting this dynamically regulated transcription factor.

       
关键字: NFATC4抗体;NFATC4;NFATC4 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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