ITGAM抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Immunofluorescence analysis of Hela cells using ITGAM mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.    

  
  

ITGAM (Integrin Alpha M), also known as CD11b, is a critical subunit of the heterodimeric transmembrane receptor Mac-1 (CD11b/CD18 or αMβ2 integrin). Expressed predominantly on myeloid cells like neutrophils, monocytes, and macrophages, it plays a pivotal role in immune responses by mediating cell adhesion, migration, and phagocytosis. ITGAM interacts with ligands such as iC3b, fibrinogen, and ICAM-1. facilitating processes like pathogen clearance, leukocyte recruitment to inflammation sites, and immune cell signaling.

Anti-ITGAM antibodies are essential tools in biomedical research and diagnostics. They are used to detect CD11b expression via flow cytometry, Western blotting, or immunohistochemistry, aiding in immune cell characterization. Dysregulation of ITGAM is linked to autoimmune diseases (e.g., systemic lupus erythematosus, rheumatoid arthritis) and inflammatory disorders. Genetic variants in ITGAM, particularly single nucleotide polymorphisms (SNPs), are associated with increased susceptibility to these conditions. Researchers employ ITGAM-blocking antibodies to study its functional roles in disease models, exploring mechanisms like leukocyte adhesion or complement receptor signaling. Additionally, therapeutic applications are under investigation, targeting ITGAM to modulate immune activation in conditions like sepsis or autoimmune pathologies. These antibodies thus bridge basic research, clinical diagnostics, and potential therapeutic development in immunology.