PNPT1抗体,Rabbit Polyclonal PNPT1 Antibody
  • PNPT1抗体,Rabbit Polyclonal PNPT1 Antibody
  • PNPT1抗体,Rabbit Polyclonal PNPT1 Antibody
  • PNPT1抗体,Rabbit Polyclonal PNPT1 Antibody

PNPT1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:PNPT1抗体英文名称:Rabbit Polyclonal PNPT1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2759 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PNPT1
2025-05-12 PNPT1抗体 Rabbit Polyclonal PNPT1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2759 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesOLD35; DFNB70; PNPASE; old-35; COXPD13
WB Predicted band size86 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human PNPT1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Jurkat cells, Hela cells, A431 cells, mouse liver tissue tissue, 293T cells, Primary antibody: P05179(PNPT1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P05179(PNPT1 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P05179(PNPT1 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于PNPT1抗体的3篇参考文献示例(注:内容为模拟生成,建议通过学术数据库验证具体信息):

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1. **标题**:*PNPT1 mutations impair mitochondrial RNA import and cause neurodegenerative disorders*

**作者**:Suzuki T, et al.

**摘要**:研究利用PNPT1抗体进行免疫印迹和免疫荧光实验,发现PNPT1突变导致线粒体RNA输入缺陷,与早发性共济失调和脑萎缩相关,揭示了其在神经退行性疾病中的分子机制。

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2. **标题**:*PNPT1-mediated mitochondrial RNA decay regulates cell survival in glioblastoma*

**作者**:Wang Y, et al.

**摘要**:通过PNPT1抗体检测胶质母细胞瘤组织中蛋白表达水平,发现PNPT1通过降解异常线粒体RNA调控肿瘤细胞凋亡,其表达下调与患者不良预后相关。

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3. **标题**:*Antibody-based profiling of PNPT1 expression in Alzheimer's disease models*

**作者**:Garcia-Sanz P, et al.

**摘要**:使用特异性PNPT1抗体分析阿尔茨海默病模型小鼠脑组织,发现PNPT1在神经元线粒体的表达减少,可能与β-淀粉样蛋白沉积导致的RNA代谢紊乱有关。

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如需具体文献,建议在PubMed或Google Scholar中搜索关键词“PNPT1 antibody”或“PNPT1 immunohistochemistry/Western blot”获取最新研究。

       

背景信息

The PNPT1 (Polyribonucleotide Nucleotidyltransferase 1) antibody is a tool used to detect and study the PNPT1 protein, a critical player in mitochondrial RNA metabolism and innate immune signaling. PNPT1. also known as mitochondrial RNA-processing protein 1. is encoded by the PNPT1 gene and localizes primarily to the mitochondrial matrix. It facilitates RNA import into mitochondria and processes RNA transcripts through its 3'-to-5' exoribonuclease activity. Mutations in PNPT1 are linked to mitochondrial disorders, neurodegenerative diseases, and hearing loss.

The PNPT1 antibody is widely utilized in research to investigate the protein's expression, localization, and function in cellular models and tissues. It aids in understanding PNPT1's role in mitochondrial dysfunction, viral RNA sensing, and its interaction with the RIG-I-like receptor pathway during antiviral responses. Available as monoclonal or polyclonal variants, the antibody is commonly validated for techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers rely on it to explore disease mechanisms, particularly those involving mitochondrial RNA dysregulation and immune signaling defects. Proper validation ensures specificity, crucial for distinguishing PNPT1 from homologous proteins.

       
关键字: PNPT1抗体;PNPT1;PNPT1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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