DCP1A抗体,Rabbit Polyclonal DCP1A Antibody
  • DCP1A抗体,Rabbit Polyclonal DCP1A Antibody
  • DCP1A抗体,Rabbit Polyclonal DCP1A Antibody
  • DCP1A抗体,Rabbit Polyclonal DCP1A Antibody

DCP1A抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
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产品详情

中文名称:DCP1A抗体英文名称:Rabbit Polyclonal DCP1A Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4008 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DCP1A
2025-05-14 DCP1A抗体 Rabbit Polyclonal DCP1A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4008 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesSMIF; SMAD4IP1; HSA275986; Nbla00360
WB Predicted band size63 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human DCP1A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: P08219(DCP1A Antibody) at dilution 1/1100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P08219(DCP1A Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08219(DCP1A Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于DCP1A抗体的3篇参考文献示例(注:内容为模拟,仅供参考):

1. **文献名称**:*DCP1A regulates mRNA decapping and P-body formation*

**作者**:Nishihara T. et al.

**摘要**:研究通过DCP1A抗体验证其在P-body(处理小体)中的定位,揭示DCP1A通过招募脱帽复合体调控mRNA降解,影响细胞应激反应和基因表达调控。

2. **文献名称**:*Interaction between DCP1A and DCP2 in the mRNA decapping complex*

**作者**:Linder B. et al.

**摘要**:利用DCP1A抗体进行免疫共沉淀实验,证明DCP1A与DCP2直接结合,协同调控mRNA脱帽过程,并影响细胞周期进程。

3. **文献名称**:*DCP1A overexpression promotes cancer cell proliferation*

**作者**:Zhang Y. et al.

**摘要**:通过Western blot和免疫组化(使用DCP1A抗体)发现DCP1A在多种癌细胞中高表达,其异常表达可能通过抑制肿瘤抑制因子的mRNA稳定性驱动肿瘤发生。

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如需真实文献,建议在PubMed或Google Scholar中检索关键词:**DCP1A antibody** + **decapping**/**P-body**/**mRNA degradation**。

       

背景信息

DCP1A (Decapping mRNA 1A) is a critical component of the mRNA decapping complex, which regulates gene expression by controlling mRNA turnover. It works alongside DCP2. EDC4. and other proteins to remove the 5' cap of mRNAs, marking them for degradation by exonucleases. This process is essential for post-transcriptional regulation, influencing cellular responses to stress, differentiation, and apoptosis. DCP1A contains conserved WD40 domains that facilitate protein-protein interactions within the decapping complex. Its activity is tightly regulated by phosphorylation and other post-translational modifications, linking it to signaling pathways like mTOR and MAPK.

Antibodies targeting DCP1A are widely used to study mRNA decay mechanisms, protein localization, and interactions in models ranging from yeast to humans. In research, these antibodies enable detection via Western blotting, immunofluorescence, and immunoprecipitation, helping to elucidate DCP1A’s role in cellular homeostasis and disease. Dysregulation of DCP1A has been implicated in cancers, neurological disorders, and viral infections, where aberrant mRNA stability contributes to pathogenesis. For example, reduced DCP1A expression correlates with tumor progression in certain cancers, suggesting its potential as a biomarker or therapeutic target. Commercial DCP1A antibodies are typically validated for specificity across species, aiding cross-disciplinary studies in molecular biology and translational medicine.

       
关键字: DCP1A抗体;DCP1A;DCP1A Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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