DPF2抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, Jurkat cells, Primary antibody: P08249(DPF2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

**Background of DPF2 Antibody**

DPF2 (Double PHD Fingers 2), also termed SMARCG1 or BAF45d, is a component of the SWI/SNF chromatin remodeling complexes, particularly the BAF (BRG1/BRM-associated factor) subfamily. Characterized by two plant homeodomain (PHD) zinc fingers, DPF2 facilitates epigenetic regulation by binding histone modifications (e.g., H3K4me0) and recruiting chromatin remodelers to modulate gene expression. It plays critical roles in cellular differentiation, embryonic development, and neural function.

Dysregulation of DPF2 is implicated in diseases such as acute myeloid leukemia (AML), where mutations disrupt chromatin remodeling, and Coffin-Siris syndrome, a neurodevelopmental disorder linked to BAF complex deficiencies. DPF2 antibodies are essential tools for detecting its expression, localization, and protein interactions via techniques like immunoblotting, immunofluorescence, and ChIP-seq. These antibodies enable studies on DPF2’s mechanistic roles in chromatin dynamics, disease pathways, and potential therapeutic targeting, particularly in cancers and genetic disorders. Research using DPF2 antibodies continues to uncover its regulatory networks, emphasizing its significance in maintaining genomic stability and cellular identity.