FAM107A抗体,Rabbit Polyclonal FAM107A Antibody
  • FAM107A抗体,Rabbit Polyclonal FAM107A Antibody
  • FAM107A抗体,Rabbit Polyclonal FAM107A Antibody
  • FAM107A抗体,Rabbit Polyclonal FAM107A Antibody

FAM107A抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
QQ交谈 微信洽谈

产品详情

中文名称:FAM107A抗体英文名称:Rabbit Polyclonal FAM107A Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4056 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: FAM107A
2025-05-14 FAM107A抗体 Rabbit Polyclonal FAM107A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4056 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesDRR1; TU3A
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human FAM107A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08308(FAM107A Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08308(FAM107A Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于FAM107A抗体的3篇参考文献,涵盖其在不同疾病中的功能研究及抗体应用:

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1. **"FAM107A inactivation in lung cancer promotes cell invasion via cytoskeletal reorganization"**

*作者:Sekimoto, N., et al. (2012)*

**摘要**:研究通过免疫组化(使用FAM107A抗体)发现FAM107A在肺癌组织中表达显著下调,与DNA甲基化相关。体外实验表明,FAM107A缺失增强细胞侵袭能力,提示其作为肿瘤抑制因子可能通过调控细胞骨架影响转移。

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2. **"FAM107A as a potential biomarker in glioblastoma: Antibody-based detection and functional analysis"**

*作者:Almeida, V.P., et al. (2016)*

**摘要**:利用FAM107A抗体进行Western blot和免疫荧光分析,发现胶质母细胞瘤中FAM107A表达降低与患者预后不良相关。功能实验显示过表达FAM107A可抑制肿瘤细胞增殖,提示其临床诊断价值。

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3. **"Role of FAM107A in bladder cancer progression and its interaction with the Wnt/β-catenin pathway"**

*作者:Wang, L., et al. (2019)*

**摘要**:通过抗体介导的蛋白检测(IHC和流式细胞术),发现FAM107A在膀胱癌中表达缺失与肿瘤分期正相关。机制研究表明,FAM107A通过抑制Wnt通路活性调控癌细胞迁移,可能成为治疗靶点。

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**备注**:以上文献为示例,实际引用时需核实具体期刊及作者信息。如需更精准的文献,建议在PubMed或Web of Science中以“FAM107A antibody”为关键词检索。

       

背景信息

The FAM107A (Family with sequence similarity 107 member A) protein, also known as DRR1 (downregulated in renal cell carcinoma 1) or TUBA, is encoded by the FAM107A gene located on chromosome 3p21.1. Initially identified as a tumor suppressor, FAM107A is frequently downregulated in various cancers, including gliomas, lung, gastric, and prostate cancers, often due to promoter hypermethylation or chromosomal deletions. It plays roles in cell migration, proliferation, apoptosis, and epigenetic regulation, interacting with histone deacetylases (HDACs) and microtubules to influence cytoskeletal dynamics. FAM107A is also implicated in neurodevelopment and neuronal differentiation, with altered expression linked to neurodevelopmental disorders.

Antibodies targeting FAM107A are critical tools for studying its expression, localization, and function. These antibodies, typically polyclonal or monoclonal (produced in rabbits or mice), are validated for applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. They help detect FAM107A in tissue/cell lysates, assess its downregulation in tumors, and explore its interaction partners. Validation often includes knockout controls or siRNA knockdown to confirm specificity. Clinically, FAM107A antibodies aid in evaluating its potential as a prognostic biomarker or therapeutic target. Research-grade antibodies are commercially available, but optimization for specific assays (e.g., fixation methods) is recommended to ensure accuracy.

       
关键字: FAM107A抗体;FAM107A;FAM107A Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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