ROM1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: TM4, 293T, 231 and Hela cell lysates, Primary antibody: P09672(ROM1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09672(ROM1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

ROM1 (Retinal Outer Segment Membrane Protein 1) is a glycoprotein encoded by the *ROM1* gene, primarily localized in the photoreceptor outer segments of the retina. It plays a critical role in maintaining the structural integrity of rod and cone photoreceptor cells by forming heterotetrameric complexes with peripherin/RDS (Retinal Degeneration Slow), another key disk membrane protein. These complexes stabilize the high-curvature edges of photoreceptor disk membranes, essential for proper disk morphogenesis and light-sensing function.

Discovered in the 1990s, ROM1 gained attention due to its association with inherited retinal diseases. Mutations in *ROM1* are linked to autosomal dominant retinitis pigmentosa (RP) and digenic RP when combined with specific *RDS/peripherin* mutations. Unlike peripherin/RDS, ROM1 is not exclusively required for disk formation but modulates disk membrane structure through its interaction with peripherin. Studies in knockout mice reveal that ROM1 deficiency leads to abnormal disk stacking, though photoreceptor degeneration is slower compared to peripherin/RDS knockouts.

ROM1 antibodies are vital tools in research, enabling the study of protein localization, interactions, and expression levels in retinal tissues. They are also used diagnostically to assess ROM1-related pathologies. Despite its smaller role compared to peripherin/RDS, ROM1 remains a focus in understanding retinal degeneration mechanisms and developing gene therapies targeting photoreceptor disorders.