The MAGOHB antibody is a tool used to detect MAGOHB, a protein encoded by the *MAGOHB* gene, which belongs to the Mago-Nashi homolog family. MAGOHB plays a critical role in the exon junction complex (EJC), a multiprotein assembly involved in mRNA splicing, export, surveillance, and translation. The EJC is deposited onto spliced mRNAs and coordinates downstream processes, including nonsense-mediated decay (NMD), which degulates faulty transcripts. MAGOHB shares structural and functional similarities with its paralog MAGOH, both forming heterodimers with proteins like RBM8A (Y14) within the EJC. However, MAGOHB exhibits distinct expression patterns and potential regulatory roles in specific tissues or developmental stages.
Research using MAGOHB antibodies has highlighted its importance in cellular homeostasis and disease. Studies suggest MAGOHB dysregulation may contribute to cancer progression, neurological disorders, or developmental defects, possibly due to disrupted mRNA processing or NMD. Antibodies against MAGOHB enable detection via techniques like Western blotting, immunofluorescence, or immunohistochemistry, aiding in exploring its localization, expression levels, and interactions in biological systems. These tools are vital for elucidating MAGOHB's role in RNA metabolism and its implications in pathological conditions, offering potential as a biomarker or therapeutic target.