EIF4A2抗体,Rabbit Polyclonal EIF4A2 Antibody
  • EIF4A2抗体,Rabbit Polyclonal EIF4A2 Antibody
  • EIF4A2抗体,Rabbit Polyclonal EIF4A2 Antibody
  • EIF4A2抗体,Rabbit Polyclonal EIF4A2 Antibody

EIF4A2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
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产品详情

中文名称:EIF4A2抗体英文名称:Rabbit Polyclonal EIF4A2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5132 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: EIF4A2
2025-05-14 EIF4A2抗体 Rabbit Polyclonal EIF4A2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5132 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesDDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II
WB Predicted band size46 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human EIF4A2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, K562 and Raji cell lysates, Primary antibody: P09906(EIF4A2 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09906(EIF4A2 Antibody) at dilution 1/80. (Original magnification: ×200)    


           

参考文献

以下是3篇关于EIF4A2抗体的参考文献示例(注:以下为虚构内容,仅用于演示格式):

1. **标题**: *EIF4A2 modulates mRNA translation in cancer cells via helicase activity regulation*

**作者**: Zhang L, et al.

**摘要**: 研究利用EIF4A2抗体通过Western blot和免疫共沉淀(Co-IP)验证其在乳腺癌细胞中的表达及与eIF4E复合物的相互作用,发现EIF4A2通过解旋酶活性调控特定致癌mRNA的翻译效率。

2. **标题**: *EIF4A2 antibody-based profiling reveals its suppression in Alzheimer’s disease neurons*

**作者**: Smith J, et al.

**摘要**: 通过免疫组化(IHC)和ELISA分析,发现阿尔茨海默病患者脑组织中EIF4A2蛋白水平显著降低,提示其可能通过影响神经元应激颗粒形成参与疾病进展。

3. **标题**: *CRISPR screening identifies EIF4A2 as a vulnerability in drug-resistant leukemia*

**作者**: Tanaka K, et al.

**摘要**: 结合EIF4A2抗体的功能验证实验,揭示敲低EIF4A2可增强化疗药物敏感性,其机制与抑制抗凋亡蛋白BCL-2的翻译相关。

(如需真实文献,建议通过PubMed或Google Scholar检索关键词“EIF4A2 antibody”、“EIF4A2 function”等。)

       

背景信息

The eukaryotic initiation factor 4A2 (EIF4A2) is a member of the DEAD-box RNA helicase family, playing a critical role in translation initiation by unwinding secondary structures in mRNA 5'UTRs to facilitate ribosome scanning. Unlike its paralog EIF4A1. which is ubiquitously expressed and integral to the canonical cap-binding complex EIF4F, EIF4A2 exhibits tissue-specific expression and participates in both cap-dependent and alternative translation mechanisms. It is implicated in specialized regulatory processes, including microRNA-mediated repression and stress-adaptive translation, often functioning within the EIF4H complex or interacting with RNA-binding proteins like DAP5 (P97) to modulate specific mRNA subsets.

EIF4A2 antibodies are essential tools for studying its expression, localization, and interactions in diverse biological contexts. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate its role in cellular homeostasis, development, and disease. Dysregulation of EIF4A2 has been linked to cancer progression, neurological disorders, and viral infection responses, with studies highlighting its dual roles as a tumor suppressor or promoter depending on cellular context. Researchers also utilize these antibodies to explore EIF4A2's involvement in translational reprogramming under stress conditions, such as hypoxia or nutrient deprivation, and its crosstalk with oncogenic signaling pathways. Specificity validation remains crucial due to high homology with EIF4A1. requiring careful antibody selection and knockout controls.

       
关键字: EIF4A2抗体;EIF4A2;EIF4A2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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