IPO11抗体,Rabbit Polyclonal IPO11 Antibody
  • IPO11抗体,Rabbit Polyclonal IPO11 Antibody
  • IPO11抗体,Rabbit Polyclonal IPO11 Antibody
  • IPO11抗体,Rabbit Polyclonal IPO11 Antibody

IPO11抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
QQ交谈 微信洽谈

产品详情

中文名称:IPO11抗体英文名称:Rabbit Polyclonal IPO11 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5187 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: IPO11
2025-05-14 IPO11抗体 Rabbit Polyclonal IPO11 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5187 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesRanBP11
WB Predicted band size113 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human IPO11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cell, Human fetal brain tissue lysates, Primary antibody: P09972(IPO11 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09972(IPO11 Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09972(IPO11 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是3篇可能与IPO11抗体相关的参考文献示例(注:文献为假设性概括,实际引用需核实):

1. **文献名称**: *Importin-11 regulates glioma cell proliferation via nuclear transport of PTEN*

**作者**: Zhang, Y. et al.

**摘要**: 研究利用IPO11抗体通过免疫沉淀和Western blot分析,揭示IPO11通过介导PTEN的核质转运影响胶质瘤细胞增殖的机制。

2. **文献名称**: *Structural insights into the nuclear import receptor IPO11-cargo recognition*

**作者**: Pumroy, R.A. & Cingolani, G.

**摘要**: 通过冷冻电镜和IPO11抗体的表位定位,解析了IPO11与肿瘤抑制蛋白RB1的结合结构,阐明其核转运特异性。

3. **文献名称**: *IPO11 expression correlates with poor prognosis in colorectal cancer*

**作者**: Wang, L. et al.

**摘要**: 使用IPO11抗体进行免疫组化分析,发现IPO11在结直肠癌中高表达,且与患者生存率负相关,提示其作为预后标志物的潜力。

**建议**:可通过PubMed或Google Scholar以“IPO11 antibody”或“Importin-11 antibody”为关键词检索最新文献,重点关注抗体在疾病模型或分子机制研究中的应用。

       

背景信息

The IPO11 antibody targets Importin 11 (IPO11), a nuclear transport receptor belonging to the importin β family. IPO11 facilitates the transport of proteins from the cytoplasm to the nucleus by forming heterodimers with importin α adaptors, recognizing cargo proteins containing classical nuclear localization signals (NLS). It plays a critical role in maintaining cellular processes such as gene expression regulation, cell cycle progression, and genome stability. IPO11 has been implicated in cancer research due to its interaction with oncogenic proteins like β-catenin, influencing Wnt signaling and tumor progression. Studies suggest IPO11 overexpression in certain cancers (e.g., colorectal, hepatocellular carcinoma) correlates with poor prognosis, highlighting its potential as a therapeutic target or biomarker.

The IPO11 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect IPO11 expression and localization in cells or tissues. Researchers utilize it to explore IPO11's functional roles in nuclear transport mechanisms, disease pathways, and its regulatory effects on ubiquitination processes. Antibody specificity is validated through knockdown/knockout controls, ensuring reliable detection of the ~110 kDa protein. Commercial antibodies are typically raised in rabbits or mice, with reactivity across human, mouse, and rat samples. Ongoing studies aim to clarify IPO11's diverse cargo proteins and its broader implications in cellular homeostasis and disease.

       
关键字: IPO11抗体;IPO11;IPO11 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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