ATP6V0A4抗体—艾普蒂 新品

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using ATP6V0A4 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using ATP6V0A4 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human kidney tissues using ATP6V0A4 mouse mAb with DAB staining.    

  
  

The ATP6V0A4 antibody targets the ATP6V0A4 protein, a critical subunit of the vacuolar-type H+-ATPase (V-ATPase) complex. V-ATPases are proton pumps responsible for acidifying intracellular compartments and regulating pH in various tissues. The ATP6V0A4 subunit, also known as the a4 isoform, is predominantly expressed in the kidney, specifically in α-intercalated cells of the distal nephron, where it plays a key role in urinary acidification and systemic acid-base homeostasis. Mutations in the ATP6V0A4 gene are linked to autosomal recessive distal renal tubular acidosis (dRTA), a disorder characterized by impaired urinary acid excretion, metabolic acidosis, and hypokalemia.

ATP6V0A4 antibodies are widely used in research to study the expression, localization, and functional role of this subunit in physiological and pathological contexts. They are essential tools for investigating dRTA mechanisms, renal physiology, and V-ATPase-related cellular processes. These antibodies are also employed in diagnostics to identify genetic or acquired defects in proton pump function. By enabling precise detection via techniques like immunohistochemistry, Western blotting, or immunofluorescence, ATP6V0A4 antibodies contribute to advancing understanding of acid-base regulation and developing targeted therapies for renal and systemic disorders involving V-ATPase dysfunction.