KHDRBS3 antibody is a research tool designed to detect the KHDRBS3 protein, a member of the Signal Transduction Associated (STA) family of RNA-binding proteins. Also known as SLM2 or KH RNA-binding domain-containing protein 3. KHDRBS3 contains conserved K-homology (KH) domains that mediate interactions with RNA and proteins. It plays roles in RNA metabolism, including splicing, stability, and translation, and is implicated in cellular processes such as development, differentiation, and stress responses. KHDRBS3 is expressed in various tissues, with higher levels observed in the brain, testes, and certain cancer cells.
The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study KHDRBS3's expression patterns, subcellular localization, and molecular interactions. Research highlights its potential involvement in neurological disorders, cancer progression, and germ cell development. For example, KHDRBS3 may regulate alternative splicing events linked to tumorigenesis or neuronal function. Commercial antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown.
Despite its emerging significance, KHDRBS3's precise mechanisms remain under investigation, and the antibody serves as a critical reagent for elucidating its biological and pathological roles. Studies using this antibody contribute to understanding RNA-binding protein networks and their impact on disease pathways.