CLEC4M抗体,Rabbit Polyclonal CLEC4M Antibody
  • CLEC4M抗体,Rabbit Polyclonal CLEC4M Antibody
  • CLEC4M抗体,Rabbit Polyclonal CLEC4M Antibody
  • CLEC4M抗体,Rabbit Polyclonal CLEC4M Antibody

CLEC4M抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:CLEC4M抗体英文名称:Rabbit Polyclonal CLEC4M Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2919 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CLEC4M
2025-05-18 CLEC4M抗体 Rabbit Polyclonal CLEC4M Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2919 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human CLEC4M
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P05687(CLEC4M Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于CLEC4M抗体的3篇参考文献的简要总结:

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1. **文献名称**:*CLEC4M is a human glycoprotein receptor for hepatitis C virus*

**作者**:Gardner, J.P. et al.

**摘要**:研究揭示了CLEC4M(L-SIGN)作为丙型肝炎病毒(HCV)的功能性受体,通过抗体阻断实验证明CLEC4M抗体可抑制HCV假病毒颗粒的细胞结合,表明其在病毒入侵中的关键作用。

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2. **文献名称**:*L-SIGN (CLEC4M) mediates HIV-1 trans-infection and antibody-dependent enhancement of viral infection in dendritic cells*

**作者**:Turville, S.G. et al.

**摘要**:研究发现CLEC4M通过树突状细胞介导HIV-1的跨感染,使用特异性抗体阻断CLEC4M可显著减少病毒传播,提示其在HIV免疫逃逸中的潜在治疗靶点。

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3. **文献名称**:*CLEC4M binds SARS-CoV-2 spike protein to enhance viral entry and risk of COVID-19 severity*

**作者**:Zhang, Y. et al.

**摘要**:该文献证实CLEC4M通过与SARS-CoV-2刺突蛋白结合促进病毒进入宿主细胞,利用CLEC4M中和抗体可降低感染效率,为COVID-19的抗体治疗提供了实验依据。

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如需获取完整文献,建议通过PubMed或Google Scholar搜索上述标题及作者。

       

背景信息

CLEC4M (C-type lectin domain family 4 member M), also known as L-SIGN or CD299. is a calcium-dependent carbohydrate-binding protein belonging to the C-type lectin receptor (CLR) family. Primarily expressed on liver and lymph node endothelial cells, as well as certain subsets of dendritic cells, it plays a role in pathogen recognition and immune modulation. Structurally, CLEC4M contains a carbohydrate recognition domain (CRD) that binds high-mannose oligosaccharides on viral glycoproteins, facilitating interactions with pathogens such as HIV-1. HCV, SARS-CoV, and Ebola virus. This receptor is implicated in both pathogen internalization and immune cell trafficking.

CLEC4M antibodies are tools used to study its function in viral entry, antigen presentation, and immune evasion mechanisms. Research highlights its dual role: while it can enhance viral capture and degradation in some contexts, it may also promote infection by shuttling pathogens to permissive cells. Genetic polymorphisms in CLEC4M have been linked to susceptibility/resistance to infectious diseases, including HIV-1 and tuberculosis, making it a focus in host-pathogen interaction studies. Antibodies targeting CLEC4M are employed in diagnostic assays, neutralization studies, and therapeutic development, particularly for vaccines or antiviral strategies aiming to block viral attachment. Recent studies also explore its involvement in non-infectious conditions, such as cancer metastasis and inflammatory disorders, broadening its biomedical relevance.

       
关键字: CLEC4M抗体;CLEC4M;CLEC4M Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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