KLRC2抗体,Rabbit Polyclonal KLRC2 Antibody
  • KLRC2抗体,Rabbit Polyclonal KLRC2 Antibody
  • KLRC2抗体,Rabbit Polyclonal KLRC2 Antibody
  • KLRC2抗体,Rabbit Polyclonal KLRC2 Antibody

KLRC2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:KLRC2抗体英文名称:Rabbit Polyclonal KLRC2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2930 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: KLRC2
2025-05-18 KLRC2抗体 Rabbit Polyclonal KLRC2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2930 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesNKG2C; CD159c; NKG2-C
WB Predicted band size26 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human KLRC2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: K562, Jurkat, MCF-7 and 293T cell, Primary antibody: P05736(KLRC2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05736(KLRC2 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P05736(KLRC2 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于KLRC2抗体的模拟参考文献示例(注:内容为虚构,仅作格式参考):

1. **标题**:NKG2C (KLRC2) Antibody Characterization in Cytomegalovirus Infection

**作者**:Smith A, et al.

**摘要**:研究通过流式细胞术验证KLRC2抗体的特异性,发现其在CMV感染者中可有效标记NKG2C+ NK细胞,揭示NKG2C与病毒免疫应答的关联。

2. **标题**:KLRC2-Specific Antibodies in Tumor-Infiltrating Lymphocyte Analysis

**作者**:Lee B, et al.

**摘要**:利用KLRC2抗体分析肿瘤微环境中NK细胞亚群,发现NKG2C高表达与患者生存率改善相关,提示其作为免疫治疗生物标志物的潜力。

3. **标题**:Genetic Variation of KLRC2 and Antibody-Based Phenotyping

**作者**:Garcia C, et al.

**摘要**:结合基因测序与KLRC2抗体检测,证实KLRC2基因多态性影响NK细胞表面NKG2C蛋白表达水平,为个体化免疫研究提供依据。

4. **标题**:Role of KLRC2 in HIV Progression: Antibody-Driven Functional Assays

**作者**:Johnson R, et al.

**摘要**:通过KLRC2抗体阻断实验,发现NKG2C+ NK细胞在HIV感染中具有抑制病毒复制的作用,提示靶向KLRC2的潜在治疗策略。

(注:以上文献信息为模拟生成,实际引用需查询真实数据库如PubMed。)

       

背景信息

The KLRC2 antibody targets the protein encoded by the *KLRC2* gene, also known as NKG2C (Natural Killer Group 2. member C). This protein is a type II transmembrane receptor predominantly expressed on natural killer (NK) cells and certain cytotoxic T lymphocytes. It forms heterodimers with CD94. creating the CD94/NKG2C receptor complex, which recognizes HLA-E molecules on target cells. HLA-E typically presents peptides derived from other HLA class I molecules, enabling NK cells to monitor cellular health. Activation of the CD94/NKG2C receptor generally transmits inhibitory or activating signals depending on associated adaptor proteins, though NKG2C is primarily linked to activating functions through its interaction with DAP12.

KLRC2 antibodies are essential tools for studying NK cell biology, particularly in viral infections (e.g., cytomegalovirus) and cancer immunology, where NKG2C+ NK cells exhibit adaptive-like features. These antibodies are used in flow cytometry, immunohistochemistry, and functional assays to characterize NK cell subsets, receptor expression dynamics, and cytotoxic responses. Dysregulation of KLRC2 expression has been implicated in autoimmune disorders, chronic infections, and transplant outcomes, making its antibody valuable for both research and clinical diagnostics. Commercial KLRC2 antibodies are typically validated for specificity against recombinant or endogenous proteins, with applications spanning basic immunology to therapeutic development.

       
关键字: KLRC2抗体;KLRC2;KLRC2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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