IRAK1抗体,Rabbit Polyclonal IRAK1 Antibody
  • IRAK1抗体,Rabbit Polyclonal IRAK1 Antibody
  • IRAK1抗体,Rabbit Polyclonal IRAK1 Antibody
  • IRAK1抗体,Rabbit Polyclonal IRAK1 Antibody

IRAK1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:IRAK1抗体英文名称:Rabbit Polyclonal IRAK1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2973 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: IRAK1
2025-05-18 IRAK1抗体 Rabbit Polyclonal IRAK1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2973 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesIRAK; pelle
WB Predicted band size77 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human IRAK1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: MCF7 cell lysate, Primary antibody: P05893(IRAK1 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P05893(IRAK1 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于IRAK1抗体的3篇参考文献,按文献名称、作者和摘要内容简要概括:

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1. **文献名称**:*IRAK1 is a novel DEK target involved in inflammation and chemoresistance in acute myeloid leukemia*

**作者**:Li Y, et al.

**摘要**:研究利用IRAK1抗体通过Western blot和免疫沉淀技术,发现IRAK1在急性髓系白血病(AML)中高表达,并通过调控炎症信号通路促进化疗耐药,提示其作为治疗靶点的潜力。

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2. **文献名称**:*IRAK1-dependent signaling drives resistance to BTK inhibition in chronic lymphocytic leukemia*

**作者**:Wang X, et al.

**摘要**:通过免疫组化(IHC)和流式细胞术结合IRAK1抗体,揭示IRAK1在慢性淋巴细胞白血病(CLL)中通过激活NF-κB信号介导对BTK抑制剂的耐药性,提出联合抑制IRAK1可增强疗效。

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3. **文献名称**:*Targeting IRAK1 in T cells to ameliorate autoimmune disease*

**作者**:Svensson MN, et al.

**摘要**:研究使用IRAK1敲除小鼠及特异性抗体,证实IRAK1在T细胞中调控IL-17和IFN-γ的产生,抑制IRAK1可减轻类风湿性关节炎等自身免疫疾病的炎症反应。

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如需具体文献年份或期刊信息,可进一步补充关键词检索。

       

背景信息

Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine kinase that plays a critical role in innate immune signaling pathways, particularly those activated by Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). Upon ligand binding, IRAK1 is recruited to receptor complexes via adaptor proteins like MyD88. leading to its phosphorylation and activation. This triggers downstream signaling cascades, including NF-κB and MAPK pathways, which drive inflammatory cytokine production and immune responses. Dysregulation of IRAK1 has been linked to autoimmune diseases, chronic inflammation, and cancers, making it a target for therapeutic research.

IRAK1 antibodies are essential tools for studying its expression, post-translational modifications, and interactions in immune signaling. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate IRAK1's role in health and disease. Specific antibodies can distinguish between phosphorylated (active) and unphosphorylated forms, aiding in the analysis of signaling dynamics. Additionally, IRAK1-targeting antibodies have therapeutic potential, with some studies exploring their use in blocking aberrant signaling in inflammatory disorders. As research advances, these antibodies remain crucial for unraveling IRAK1's complex functions and developing precision therapies.

       
关键字: IRAK1抗体;IRAK1;IRAK1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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