GPR146抗体,Rabbit Polyclonal GPR146 Antibody
  • GPR146抗体,Rabbit Polyclonal GPR146 Antibody
  • GPR146抗体,Rabbit Polyclonal GPR146 Antibody
  • GPR146抗体,Rabbit Polyclonal GPR146 Antibody

GPR146抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:GPR146抗体英文名称:Rabbit Polyclonal GPR146 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3180 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GPR146
2025-05-18 GPR146抗体 Rabbit Polyclonal GPR146 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3180 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesPGR8
WB Predicted band size36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human GPR146
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A172 cell lysate, Primary antibody: P06596(GPR146 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P06596(GPR146 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06596(GPR146 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于GPR146抗体的虚构参考文献示例,格式为文献名称、作者及摘要概括:

1. **"Development of a High-Specificity Antibody for GPR146 and Its Application in Hepatic Tissue Analysis"**

*Authors: Zhang L, et al.*

摘要:本研究报道了一种针对GPR146的高特异性多克隆抗体的开发,通过免疫印迹和免疫组化验证其在肝组织中的表达,证实GPR146在脂质代谢相关细胞中的定位,为代谢疾病研究提供工具。

2. **"GPR146 Antibody-Based Blockade Attenuates Atherosclerosis in Mouse Models"**

*Authors: Patel R, et al.*

摘要:利用抗GPR146中和抗体抑制受体活性,发现可减少小鼠动脉粥样硬化斑块形成,提示GPR146在血管炎症中的作用,抗体干预可能成为潜在治疗策略。

3. **"Characterization of GPR146 Signaling in Pancreatic β-Cells Using CRISPR/Cas9 and Antibody-Mediated Detection"**

*Authors: Kim S, et al.*

摘要:通过CRISPR/Cas9敲除GPR146并结合特异性抗体检测,揭示该受体在胰岛β细胞胰岛素分泌中的调控机制,强调其与2型糖尿病病理的关联。

4. **"A Novel Monoclonal Antibody Targeting GPR146 Reveals Sex-Specific Expression in Adipose Tissue"**

*Authors: Müller J, et al.*

摘要:开发了一种单克隆抗体用于检测GPR146.发现其在雌性小鼠脂肪组织中的表达显著高于雄性,提示性别差异可能影响GPR146在肥胖中的作用研究。

(注:上述文献为虚构示例,实际研究中请通过学术数据库查询真实文献。)

       

背景信息

The G protein-coupled receptor 146 (GPR146), also known as PGR8. is an orphan receptor belonging to the class A GPCR family. Its endogenous ligand and precise physiological roles remain poorly characterized, though emerging evidence suggests involvement in metabolic regulation, particularly lipid and glucose homeostasis. GPR146 is expressed in various tissues, including the liver, pancreas, and cardiovascular system, and has been linked to conditions such as atherosclerosis, diabetes, and hepatic steatosis in preclinical studies. Due to the lack of definitive functional data, research tools like antibodies are critical for elucidating its expression patterns and mechanisms.

GPR146 antibodies are typically developed using immunogens derived from conserved regions of its extracellular or intracellular domains, such as synthetic peptides or recombinant protein fragments. These antibodies enable detection of endogenous GPR146 via techniques like Western blotting, immunohistochemistry, and flow cytometry. Validation often includes testing in knockout models or siRNA-treated cells to confirm specificity. Commercially available antibodies vary in host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal), with applications spanning basic research to biomarker studies. Challenges include low endogenous expression levels in certain tissues and potential cross-reactivity with homologous GPCRs. Ongoing studies using these antibodies aim to clarify GPR146's signaling pathways and its potential as a therapeutic target for metabolic disorders.

       
关键字: GPR146抗体;GPR146;GPR146 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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