HIC2抗体,Rabbit Polyclonal HIC2 Antibody
  • HIC2抗体,Rabbit Polyclonal HIC2 Antibody
  • HIC2抗体,Rabbit Polyclonal HIC2 Antibody
  • HIC2抗体,Rabbit Polyclonal HIC2 Antibody

HIC2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:HIC2抗体英文名称:Rabbit Polyclonal HIC2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3218 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HIC2
2025-05-18 HIC2抗体 Rabbit Polyclonal HIC2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3218 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesHRG22; ZBTB30; ZNF907
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human HIC2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer using P06688(HIC2 Antibody) at dilution 1/75. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer using P06688(HIC2 Antibody) at dilution 1/75. (Original magnification: ×200)    


           

参考文献

以下是关于HIC2抗体的3篇参考文献(示例为虚构内容,实际文献需根据数据库查询):

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1. **文献名称**: "HIC2 regulates cardiac development through transcriptional activation of myocyte enhancer factors"

**作者**: Smith A, et al. (2021)

**摘要**: 本研究利用HIC2特异性抗体进行免疫共沉淀和染色质免疫荧光分析,发现HIC2通过结合心脏发育相关基因的启动子区域调控其表达,在小鼠模型中证实其缺失导致心脏形态异常。

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2. **文献名称**: "Epigenetic silencing of HIC2 by hypermethylation promotes tumor progression in colorectal cancer"

**作者**: Johnson R, et al. (2020)

**摘要**: 通过Western blot和免疫组化(使用HIC2单克隆抗体)发现,结直肠癌组织中HIC2蛋白表达显著下调,其启动子高甲基化状态与患者不良预后相关,体外实验表明HIC2抑制肿瘤细胞增殖。

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3. **文献名称**: "HIC2 interacts with BCL6 to modulate chromatin remodeling in B-cell lymphomas"

**作者**: Lee S, et al. (2019)

**摘要**: 研究采用HIC2抗体进行ChIP-seq和免疫共沉淀实验,揭示HIC2与BCL6形成复合物,通过调节染色质结构影响淋巴瘤细胞的基因表达谱,为靶向治疗提供新思路。

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4. **文献名称**: "Dynamic subcellular localization of HIC2 during the cell cycle revealed by antibody-based imaging"

**作者**: Brown K, et al. (2018)

**摘要**: 利用HIC2多克隆抗体进行免疫荧光和流式细胞术分析,发现HIC2在细胞周期不同阶段的核内定位存在动态变化,提示其可能参与DNA复制或损伤修复过程。

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(注:以上文献为示例,实际引用需查询PubMed、Google Scholar等数据库获取真实信息。)

       

背景信息

The HIC2 (Hypermethylated in Cancer 2) antibody is a tool used to study the HIC2 protein, encoded by the HIC2 gene located on human chromosome 22q11.21. HIC2 functions as a transcriptional regulator belonging to the BTB/POZ zinc finger protein family, implicated in diverse biological processes, including cell proliferation, differentiation, and apoptosis. Initially identified as a tumor suppressor, HIC2 is frequently epigenetically silenced via hypermethylation in various cancers, such as colorectal and breast cancer, correlating with poor prognosis. Beyond oncology, HIC2 plays critical roles in cardiovascular development, particularly in heart morphogenesis and outflow tract septation, as evidenced by studies in mouse models.

The HIC2 antibody is widely utilized in research to detect and quantify HIC2 protein expression via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It aids in exploring HIC2's interaction networks, subcellular localization (primarily nuclear), and regulatory mechanisms. Researchers also employ this antibody to investigate HIC2's role in DNA damage response and its cross-talk with signaling pathways like p53 and Wnt. Commercial HIC2 antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown. Despite its utility, challenges remain in standardizing detection protocols across tissue types due to variable expression levels. Ongoing studies aim to clarify HIC2's dual roles in tumor suppression and developmental biology, highlighting its potential as a therapeutic target or diagnostic marker.

       
关键字: HIC2抗体;HIC2;HIC2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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