Amifostine trihydrate CAS:112901-68-5
Description:White crystalline powder
Assay: NLT99.5%(Including crystal water)
Product Name: Amifostine trihydrate; Amifostine 3H2O; WR2721; WR-2721; Ethyol;Ethiophos; Gammaphos; SAPEP
CAS No.: 112901-68-5
Synonyms: 2-(3-Aminopropylamino)ethylsulfanylphosphonic acid trihydrate; 2-(3-Aminopropyl)aminoethyl phosphorothioate;1-(dihydrogen phosphate) 2-[(3-aminopropyl)amino]-ethanethiol, trihydrate
Molecular Formula: C5H21N2O6PS; C5H15N2O3PS.3H2O
Molecular weight: 268.27
Application: Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible. Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.
Amifostine is a prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities. Because of the differential expression of alkaline phosphatase in normal versus neoplastic tissues, the cytoprotection conferred by amifostine is selective, enabling as much as 100-fold greater accumulation of WR 1065 in normal tissues than in tumor cells.Amifostine has been used to reduce toxicity in normal tissues exposed to radiation or chemotherapeutic agents.In mouse fibroblasts and various cancer cells, amifostine (IC50 ~4 mM) has been shown to activate p53 protein, to induce the expression of the cyclin-dependent kinase inhibitor p21, and to arrest cells at the G1/S transition through a p53-dependent mechanism. Amifostine is a chemopreventive drug used to selectively protect normal tissues from the side effects of chemotherapy drugs such as cyclophosphmide, mitomucin-C and cisplatin, and ionising radiation therapy. Amifostine is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents.
关键字： Amifostine trihydrate
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