COX7A2抗体,Rabbit Polyclonal COX7A2 Antibody
  • COX7A2抗体,Rabbit Polyclonal COX7A2 Antibody
  • COX7A2抗体,Rabbit Polyclonal COX7A2 Antibody
  • COX7A2抗体,Rabbit Polyclonal COX7A2 Antibody

COX7A2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:COX7A2抗体英文名称:Rabbit Polyclonal COX7A2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3289 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: COX7A2
2025-05-18 COX7A2抗体 Rabbit Polyclonal COX7A2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3289 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesVIIAL; COX7AL; COX7AL1; COXVIIAL; COXVIIa-L
WB Predicted band size9 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human COX7A2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P06868(COX7A2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P06868(COX7A2 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于COX7A2抗体的参考文献示例(注:以下内容为示例性概括,非真实文献):

1. **文献名称**:*COX7A2 regulates mitochondrial function and promotes tumor progression in colorectal cancer*

**作者**:Chen et al.

**摘要**:通过COX7A2抗体检测发现,其在结直肠癌组织中表达显著下调,与线粒体呼吸活性降低相关,提示COX7A2可能通过调控细胞能量代谢影响肿瘤进展。

2. **文献名称**:*Tissue-specific expression of COX7A2 isoforms in mammalian skeletal muscle*

**作者**:Smith et al.

**摘要**:利用COX7A2抗体进行免疫印迹和免疫荧光实验,揭示COX7A2在不同肌肉纤维类型中的差异表达,提示其与运动适应性代谢调控相关。

3. **文献名称**:*COX7A2 deficiency exacerbates cardiac hypertrophy via mitochondrial dysfunction*

**作者**:Wang et al.

**摘要**:研究通过COX7A2抗体敲除模型,发现COX7A2缺失导致心肌细胞线粒体复合物IV活性下降,加剧心脏肥大和心力衰竭。

4. **文献名称**:*COX7A2 as a biomarker for early detection of Parkinson’s disease*

**作者**:Garcia-Ruiz et al.

**摘要**:采用COX7A2抗体分析患者脑脊液样本,发现其表达水平与帕金森病早期病理相关,或可作为潜在诊断标志物。

(注:以上文献为模拟示例,实际引用需查询具体数据库如PubMed、Web of Science等。)

       

背景信息

The COX7A2 antibody is a crucial tool for studying the cytochrome c oxidase (COX) complex, a key component of the mitochondrial electron transport chain (ETC) involved in cellular energy production. COX, or Complex IV, catalyzes the final step of oxidative phosphorylation, transferring electrons to oxygen to form water while driving ATP synthesis. The COX7A2 protein is one of several nuclear-encoded subunits of Complex IV, specifically part of the catalytic core. It exists in two tissue-specific isoforms: COX7A1 (ubiquitous) and COX7A2. which is predominantly expressed in skeletal muscle and heart, reflecting its role in high-energy-demand tissues.

Antibodies targeting COX7A2 enable researchers to investigate its expression, localization, and regulation in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in diseases linked to mitochondrial dysfunction, such as metabolic disorders, neurodegenerative conditions, and cancer. For instance, altered COX7A2 expression has been observed in mitochondrial myopathies and tumors, where metabolic reprogramming is a hallmark. These antibodies also aid in exploring tissue-specific COX assembly mechanisms and responses to stressors like hypoxia or exercise. Validated COX7A2 antibodies are essential for ensuring specificity, given the high homology among COX subunits. Their application advances understanding of mitochondrial biology, disease mechanisms, and potential therapeutic targets.

       
关键字: COX7A2抗体;COX7A2;COX7A2 Antibody;

公司简介

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主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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