The SULT1B1 (sulfotransferase family 1B member 1) antibody is a tool used to detect and study the SULT1B1 enzyme, a member of the cytosolic sulfotransferase family. SULT1B1 plays a critical role in phase II biotransformation, catalyzing the sulfonation of hormones, neurotransmitters, and xenobiotics (e.g., drugs, environmental toxins) to enhance their solubility for excretion. Primarily expressed in the gastrointestinal tract, liver, and immune cells, it targets substrates like thyroid hormones, estrogens, and dietary flavonoids. Dysregulation of SULT1B1 has been linked to metabolic disorders, cancer progression (e.g., colorectal cancer), and altered drug metabolism.
The SULT1B1 antibody is widely employed in research to analyze protein expression, localization, and function via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It aids in understanding tissue-specific expression patterns, enzyme activity modulation, and its role in detoxification or bioactivation of compounds. Commercial SULT1B1 antibodies are typically validated for specificity using knockout controls or siRNA-mediated silencing. Researchers also utilize it to explore associations between SULT1B1 polymorphisms and disease susceptibility. As a key reagent in metabolic and pharmacological studies, this antibody supports insights into enzyme-driven pathways and therapeutic target development.