UBA7抗体,Rabbit Polyclonal UBA7 Antibody
  • UBA7抗体,Rabbit Polyclonal UBA7 Antibody
  • UBA7抗体,Rabbit Polyclonal UBA7 Antibody
  • UBA7抗体,Rabbit Polyclonal UBA7 Antibody

UBA7抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
QQ交谈 微信洽谈

产品详情

中文名称:UBA7抗体英文名称:Rabbit Polyclonal UBA7 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4458 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: UBA7
2025-05-19 UBA7抗体 Rabbit Polyclonal UBA7 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4458 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesD8; UBE2; UBA1B; UBE1L
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human UBA7
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08932(UBA7 Antibody) at dilution 1/110. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P08932(UBA7 Antibody) at dilution 1/110. (Original magnification: ×200)    


           

参考文献

以下是3篇与UBA7(UBE1L)抗体相关的代表性文献,供参考:

---

1. **"The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase"**

*作者:Zou W, Zhang DE*

摘要:该研究揭示了UBA7(UBE1L)作为ISG15激活酶,与泛素化系统协同调控干扰素信号通路,并在肺癌细胞中通过ISGylation修饰抑制致癌蛋白如STAT1的机制。

---

2. **"UBA7 is a critical regulator of protein ISGylation during influenza virus infection"**

*作者:Kim KI, Giannakopoulos NV, Virgin HW, et al.*

摘要:通过使用UBA7特异性抗体,本文证明病毒感染中UBA7介导的ISGylation修饰可抑制病毒复制,并揭示了其在先天免疫应答中的关键作用。

---

3. **"UBE1L deficiency induces tumor cell apoptosis through ISG15-mediated ER stress in colorectal cancer"**

*作者:Jeon YJ, Yoo HM, Chung CH*

摘要:研究发现结直肠癌中UBA7表达下调导致内质网应激增强,通过抗体检测证实其缺失通过ISG15依赖的未折叠蛋白反应(UPR)促进肿瘤细胞凋亡。

---

**备注**:以上文献为示例性质,实际引用需核对原文准确性。建议通过PubMed或Web of Science以“UBA7 antibody”或“UBE1L ISGylation”为关键词获取最新研究。

       

背景信息

UBA7 (Ubiquitin-like modifier-activating enzyme 7), also known as UBE2L7. is a member of the E2 ubiquitin-conjugating enzyme family. It plays a critical role in the ubiquitin-proteasome system (UPS), which regulates protein degradation and cellular homeostasis. Specifically, UBA7 is essential for activating and transferring ubiquitin-like protein ISG15 (interferon-stimulated gene 15) to target proteins, a process vital for antiviral immune responses and inflammatory regulation. This enzyme is induced by type I interferons, linking it to innate immunity and host defense mechanisms against viral infections.

UBA7 antibodies are crucial tools for studying its expression, localization, and function in various biological contexts. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate UBA7’s role in diseases such as cancer, autoimmune disorders, and neurodegenerative conditions. Dysregulation of UBA7 has been implicated in tumorigenesis due to its impact on protein stability and signaling pathways. Additionally, research highlights its interaction with viral proteins, suggesting therapeutic targeting potential.

Commercial UBA7 antibodies are typically validated for specificity using knockout cell lines or siRNA knockdown. Researchers prioritize antibodies with high affinity and minimal cross-reactivity to related E2 enzymes. Understanding UBA7’s molecular mechanisms through these antibodies advances insights into UPS-related pathologies and therapeutic strategies.

       
关键字: UBA7抗体;UBA7;UBA7 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

UBA7抗体—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
询价
VIP1年
上海切尔齐生物科技有限公司
2025-05-30
询价
VIP3年
维百奥(北京)生物科技有限公司
2025-10-27
¥1800
VIP1年
费雪(杭州)医学研究有限公司
2025-11-03
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.