Mouse Monoclonal PTH Antibody,Mouse Monoclonal PTH Antibody
  • Mouse Monoclonal PTH Antibody,Mouse Monoclonal PTH Antibody
  • Mouse Monoclonal PTH Antibody,Mouse Monoclonal PTH Antibody
  • Mouse Monoclonal PTH Antibody,Mouse Monoclonal PTH Antibody

PTH抗体;PTH Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:Mouse Monoclonal PTH Antibody英文名称:Mouse Monoclonal PTH Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1355 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: PTH
2025-05-25 Mouse Monoclonal PTH Antibody Mouse Monoclonal PTH Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1355 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesFIH1; PTH1
Entrez GeneID5741
clone8C5H9
WB Predicted band size12.8kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PTH (AA: 32-115) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using PTH mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using PTH mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HepG2 cells using PTH mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using PTH mouse mAb with DAB staining.    


           

参考文献

以下是关于PTH抗体的3篇代表性文献示例(内容为模拟概括,非真实引用):

1. **《Parathyroid hormone autoantibodies in hypocalcemic patients: clinical implications》**

- **作者**: Smith A, et al.

- **摘要**: 研究报道了3例因PTH自身抗体导致严重低钙血症的病例,抗体干扰了PTH检测并阻断其生物活性,提示自身免疫性疾病中需警惕此类罕见病因。

2. **《Interference of endogenous antibodies in parathyroid hormone immunoassays: a multicenter study》**

- **作者**: Johnson R, et al.

- **摘要**: 通过分析1200例患者样本,发现约0.5%的病例存在PTH检测假性异常(高值或低值),其中多数与异嗜性抗体或PTH特异性自身抗体相关,建议临床结合其他指标验证。

3. **《Comparison of second- and third-generation PTH assays in chronic kidney disease patients》**

- **作者**: Lee C, et al.

- **摘要**: 比较不同代际PTH检测方法(如全段PTH与生物活性PTH测定)在肾病患者中的差异,发现某些检测可能因抗体交叉反应导致结果偏差,影响继发性甲旁亢的诊断准确性。

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**说明**:

1. 真实文献需通过PubMed/Google Scholar检索关键词如 **"PTH antibody interference"** 或 **"parathyroid hormone autoantibodies"** 获取。

2. 临床相关研究多聚焦于抗体对检测的干扰机制(如假性PTH升高/降低)或自身抗体引发的代谢异常(如低钙血症)。

3. 建议补充检索方向:甲状旁腺功能减退症、多发性内分泌自身免疫综合征等疾病中的PTH抗体研究。

       

背景信息

Parathyroid hormone (PTH) antibodies are specialized immunoglobulins designed to target and bind to PTH, a peptide hormone produced by the parathyroid glands. PTH plays a critical role in calcium and phosphorus homeostasis by regulating bone resorption, renal calcium reabsorption, and vitamin D metabolism. PTH antibodies are primarily utilized in research and clinical diagnostics to measure PTH levels in serum or plasma, aiding in the diagnosis and management of disorders like hyperparathyroidism, hypoparathyroidism, and chronic kidney disease-related mineral imbalances.

These antibodies are classified as monoclonal or polyclonal, depending on their specificity and application. Monoclonal antibodies, generated from identical immune cells, offer high specificity for distinct PTH epitopes, while polyclonal antibodies recognize multiple epitopes, enhancing detection sensitivity. In immunoassays (e.g., ELISA, chemiluminescence), PTH antibodies help differentiate intact PTH (biologically active) from inactive fragments, improving diagnostic accuracy.

Beyond diagnostics, PTH antibodies are explored therapeutically. For instance, antibody-based therapies targeting PTH or its receptor are under investigation for conditions like osteoporosis or hypercalcemia. However, their clinical use remains limited compared to diagnostic applications. Recent advances include engineered antibody fragments for targeted drug delivery or imaging in parathyroid-related pathologies. Challenges persist in minimizing cross-reactivity with PTH-related peptides and ensuring stability in assay environments. Overall, PTH antibodies remain indispensable tools for understanding and managing calcium-related disorders.

       
关键字: PTH抗体;PTH;PTH Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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