CLEC2抗体,Mouse Monoclonal CLEC2 Antibody
  • CLEC2抗体,Mouse Monoclonal CLEC2 Antibody
  • CLEC2抗体,Mouse Monoclonal CLEC2 Antibody
  • CLEC2抗体,Mouse Monoclonal CLEC2 Antibody

CLEC2抗体;CLEC2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:CLEC2抗体英文名称:Mouse Monoclonal CLEC2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1440 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CLEC2
2025-05-25 CLEC2抗体 Mouse Monoclonal CLEC2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1440 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik
Entrez GeneID51266
clone4D2A6
WB Predicted band size26.6kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CLEC2 (AA: Extra(58-229)) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


  •  

     

       Flow cytometric analysis of Jurkat cells using CLEC2 mouse mAb (green) and negative control (red).    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human bladder Cancer tissues using CLEC2 mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using CLEC2 mouse mAb with DAB staining.    


           

参考文献

以下是关于CLEC2抗体的3篇代表性文献及其摘要概述:

---

1. **文献名称**:*A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2*

**作者**:Suzuki-Inoue, K. et al.

**摘要**:该研究首次揭示了CLEC2(C型凝集素受体)通过Syk激酶依赖性信号通路激活血小板的机制。实验表明,CLEC2抗体或内源性配体Podoplanin的结合会触发血小板聚集和血栓形成,为CLEC2在血栓性疾病中的作用提供了理论基础。

---

2. **文献名称**:*CLEC-2 antibodies in heparin-induced thrombocytopenia: Pathogenic role and therapeutic implications*

**作者**:Greinacher, A. et al.

**摘要**:研究探讨了CLEC2抗体在肝素诱导的血小板减少症(HIT)中的潜在作用。发现部分HIT患者体内存在针对CLEC2的自身抗体,这些抗体可能通过异常激活血小板参与血栓并发症,提示CLEC2是HIT的新型生物标志物或治疗靶点。

---

3. **文献名称**:*Targeting CLEC-2 in cancer: Dual roles in tumor angiogenesis and immune evasion*

**作者**:Christou, C.M. et al.

**摘要**:该文献分析了CLEC2抗体在肿瘤微环境中的双重作用。一方面,CLEC2与Podoplanin相互作用促进肿瘤血管生成;另一方面,阻断CLEC2可增强抗肿瘤免疫反应,为开发基于CLEC2抗体的癌症疗法提供了依据。

---

以上研究涵盖了CLEC2抗体的信号机制、疾病关联及治疗潜力,需结合具体需求进一步查阅原文。

       

背景信息

CLEC2 (C-type lectin-like receptor 2) is a transmembrane protein belonging to the C-type lectin family, primarily expressed on platelets, dendritic cells, and myeloid cells. It functions as a signaling receptor through its cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM). CLEC2 interacts with podoplanin (PDPN), a glycoprotein expressed on lymphatic endothelial cells, certain immune cells, and tumor cells. This interaction is critical in platelet activation, thrombosis, and maintenance of vascular integrity. Notably, CLEC2 binding to PDPN on lymphatic endothelial cells prevents blood-lymph mixing during development by stabilizing connections between lymphatic and blood vessels.

In pathological contexts, CLEC2-PDPN signaling contributes to cancer metastasis by promoting platelet aggregation around tumor cells, facilitating their survival in circulation. CLEC2 also regulates immune responses, influencing dendritic cell maturation and T-cell interactions. Anti-CLEC2 antibodies, often used as research tools, block CLEC2-mediated signaling and have revealed its roles in thrombosis, inflammation, and tumor progression. Therapeutic targeting of CLEC2 is explored for antithrombotic therapies or cancer treatment, though challenges remain in specificity and off-target effects. Dysregulated CLEC2 expression or signaling is implicated in autoimmune disorders and thromboinflammatory diseases, underscoring its biological and clinical relevance.

       
关键字: CLEC2抗体;CLEC2;CLEC2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

CLEC2抗体;CLEC2 Antibody—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
¥1138
VIP4年
上海沪震实业有限公司
2025-11-20
询价
VIP3年
维百奥(北京)生物科技有限公司
2025-10-27
¥1800
VIP1年
费雪(杭州)医学研究有限公司
2025-11-03
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.