ART4抗体;ART4 Antibody—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: P11482(ART4 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11482(ART4 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11482(ART4 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

ART4 (ADP-ribosyltransferase 4), also known as CD297. is a glycosylphosphatidylinositol (GPI)-anchored membrane protein belonging to the ADP-ribosyltransferase family. Initially identified for its enzymatic activity in transferring ADP-ribose groups to target proteins, ART4 is now primarily recognized as a differentiation antigen with restricted expression in normal tissues, notably in the testis. Its overexpression in certain cancers, including gastric, colorectal, and esophageal cancers, has drawn interest as a potential tumor-associated antigen.

ART4 antibodies are tools used to detect ART4 expression in research and diagnostics. Their development stems from efforts to identify cancer-specific biomarkers for targeted therapy or diagnosis. ART4’s role in cancer remains unclear but may involve immune evasion or signaling modulation through protein ADP-ribosylation. Antibodies against ART4 enable immunohistochemical staining to assess tumor expression patterns, correlate with clinical outcomes, or guide antibody-based therapies. Some studies explore ART4-targeting immunoconjugates or CAR-T cells. However, its restricted normal tissue expression reduces off-target risks, enhancing therapeutic appeal. Current research focuses on validating ART4’s functional roles and optimizing antibody specificity for clinical translation.