GRAP抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09124(GRAP Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09124(GRAP Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

GRAP (GRB2-related adapter protein) is a cytoplasmic adapter protein involved in intracellular signal transduction pathways, particularly those mediated by receptor tyrosine kinases (RTKs). Belonging to the GRB2 family of adapter proteins, GRAP facilitates the formation of multi-protein signaling complexes by linking activated cell surface receptors to downstream effectors. It contains modular domains, including an N-terminal SH3 domain and a C-terminal SH2 domain, which enable interactions with phosphorylated tyrosine residues on receptors and other signaling molecules. GRAP plays a role in regulating immune responses, T-cell development, and neural signaling, with studies implicating its involvement in diseases such as cancer and autoimmune disorders.

GRAP antibodies are essential tools for studying the protein's expression, localization, and function. They are widely used in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to detect GRAP in cell lysates, tissue samples, or experimental models. Research has shown that GRAP interacts with signaling pathways like Ras-MAPK and PI3K-AKT, influencing cell proliferation, differentiation, and apoptosis. Dysregulation of GRAP expression or activity has been observed in malignancies and inflammatory conditions, making it a potential biomarker or therapeutic target. These antibodies also aid in elucidating GRAP's crosstalk with related proteins like GRB2 and SOS1. advancing understanding of cellular communication networks.