PRRG3抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue , Primary antibody: P09130(PRRG3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

PRRG3 (Proline Rich and Gla Domain 3) is a transmembrane protein belonging to the proline-rich gamma-carboxyglutamic acid (Gla) protein family. It features an N-terminal Gla domain, which undergoes vitamin K-dependent post-translational modification, and a C-terminal proline-rich region. PRRG3 is implicated in cellular processes such as cell adhesion, signaling, and protein-protein interactions, though its precise biological functions remain under investigation. Emerging studies suggest its involvement in tumorigenesis, with altered expression observed in cancers like breast and lung adenocarcinoma, where it may influence cell proliferation or metastasis.

PRRG3 antibodies are essential tools for detecting and characterizing this protein in research. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study PRRG3 expression patterns, subcellular localization, and interactions. Some studies highlight PRRG3's potential role in neurological disorders and vascular biology, possibly linked to its expression in brain tissues and endothelial cells. Despite progress, the regulatory mechanisms of PRRG3 and its pathophysiological relevance require further exploration. Antibodies against PRRG3 thus serve as critical reagents for unraveling its functional roles and evaluating its potential as a diagnostic marker or therapeutic target in diseases.