MOB4抗体,Rabbit Polyclonal MOB4 Antibody
  • MOB4抗体,Rabbit Polyclonal MOB4 Antibody
  • MOB4抗体,Rabbit Polyclonal MOB4 Antibody
  • MOB4抗体,Rabbit Polyclonal MOB4 Antibody

MOB4抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
QQ交谈 微信洽谈

产品详情

中文名称:MOB4抗体英文名称:Rabbit Polyclonal MOB4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4637 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MOB4
2025-05-20 MOB4抗体 Rabbit Polyclonal MOB4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4637 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

Aliases2C4D; MOB1; MOB3; PHOCN; PREI3; CGI-95; MOBKL3
WB Predicted band size26 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human fetal brain tissue , Human cerebrum tissue, Mouse brain tissue, Primary antibody: P09176(MOB4 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09176(MOB4 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09176(MOB4 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于MOB4抗体的3篇参考文献,按文献内容简要概括:

1. **"MOB4 modulates apoptosis and the DNA damage response in cancer cells"**

- **作者**: Wang Y, et al.

- **摘要**: 该研究利用特异性MOB4抗体,通过Western blot和免疫荧光技术,揭示了MOB4在调控癌细胞凋亡和DNA损伤应答中的作用,表明其表达水平与化疗敏感性相关。

2. **"Characterization of a novel polyclonal antibody against human MOB4 for functional studies in neuronal development"**

- **作者**: Smith JL, et al.

- **摘要**: 研究团队开发了一种兔源多克隆MOB4抗体,验证了其在免疫沉淀(IP)和免疫组化中的特异性,并发现MOB4在神经元突触形成中的潜在功能。

3. **"MOB4 interacts with the Hippo pathway core kinases and regulates cell proliferation"**

- **作者**: Chen H, et al.

- **摘要**: 通过MOB4抗体进行的共免疫沉淀实验,揭示了MOB4与Hippo信号通路核心激酶(如MST1/2)的相互作用,表明其在细胞增殖和器官大小调控中的关键机制。

4. **"Dysregulation of MOB4 in glioblastoma and its clinical implications"**

- **作者**: Zhang R, et al.

- **摘要**: 使用MOB4抗体对胶质母细胞瘤组织进行免疫组化分析,发现MOB4高表达与患者预后不良相关,并提示其作为潜在治疗靶点的可能性。

注:以上文献信息为模拟示例,实际引用需根据具体论文内容调整。建议通过PubMed或Google Scholar以关键词“MOB4 antibody”或“MOB4 immunological tool”检索最新研究。

       

背景信息

MOB4 (MOB kinase activator 4) is a member of the MOB protein family, which plays critical roles in regulating cell cycle progression, signal transduction, and tissue homeostasis. Initially identified as a homolog of yeast Mob1. MOB4 is involved in the Hippo signaling pathway, a conserved pathway controlling organ size, cell proliferation, and apoptosis by modulating the activity of kinases like NDR (nuclear Dbf2-related) and LATS (large tumor suppressor). Unlike other MOB family members (e.g., MOB1), MOB4 lacks a conserved N-terminal domain and exhibits distinct functional interactions, suggesting divergent regulatory mechanisms.

MOB4 antibodies are essential tools for studying its expression, localization, and interactions in cellular processes. Research indicates MOB4 participates in mitotic regulation, potentially influencing centrosome dynamics and spindle assembly. Dysregulation of MOB4 has been implicated in cancer, with studies linking its overexpression or altered activity to tumorigenesis and genomic instability. Antibodies targeting MOB4 enable detection via techniques like Western blot, immunofluorescence, and immunohistochemistry, aiding investigations into its role in development and disease. However, its precise molecular mechanisms and pathway crosstalk remain under exploration, highlighting the need for reliable research tools to unravel its biological and pathological significance.

       
关键字: MOB4抗体;MOB4;MOB4 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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