The ING5 antibody is a research tool targeting the inhibitor of growth family member 5 (ING5), a protein implicated in chromatin remodeling, transcriptional regulation, and tumor suppression. ING5 belongs to the ING family of proteins, which are characterized by their plant homeodomain (PHD) and interact with histone acetyltransferase (HAT) complexes to modulate histone acetylation, influencing gene expression. Functionally, ING5 participates in cell cycle control, apoptosis, DNA repair, and differentiation. Dysregulation of ING5 has been linked to cancer progression, with studies showing its downregulation in malignancies like breast cancer, colorectal cancer, and gliomas, correlating with poor prognosis.
The ING5 antibody is widely used in molecular biology to detect ING5 expression via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It aids in studying ING5's role in tumorigenesis, its interaction with HAT complexes (e.g., MOZ/MORF), and its potential as a biomarker or therapeutic target. Commercial ING5 antibodies are typically validated for specificity and sensitivity across species, particularly human and mouse models. Recent research also explores ING5's involvement in metabolic regulation and stem cell differentiation, broadening its relevance in both cancer biology and developmental studies.