NAA60抗体,Rabbit Polyclonal NAA60 Antibody
  • NAA60抗体,Rabbit Polyclonal NAA60 Antibody
  • NAA60抗体,Rabbit Polyclonal NAA60 Antibody
  • NAA60抗体,Rabbit Polyclonal NAA60 Antibody

NAA60抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
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产品详情

中文名称:NAA60抗体英文名称:Rabbit Polyclonal NAA60 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4651 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: NAA60
2025-05-20 NAA60抗体 Rabbit Polyclonal NAA60 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4651 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesHAT4; NAT15
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09194(NAA60 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09194(NAA60 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于NAA60抗体的3篇参考文献及其摘要内容的简要总结:

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1. **文献名称**: *NAA60 is a Golgi-localized bifunctional acetyltransferase essential for membrane protein targeting*

**作者**: Aksnes, H., Van Damme, P., Goris, M., et al.

**摘要**: 该研究首次报道了NAA60(又称HAT4)作为高尔基体定位的乙酰转移酶,介导跨膜蛋白的N端乙酰化,调控膜蛋白的亚细胞定位和稳定性。研究利用特异性抗体证实了NAA60在高尔基体的分布及其与膜蛋白的相互作用。

2. **文献名称**: *The N-terminal acetyltransferase Naa60 regulates cellular redox homeostasis in Drosophila*

**作者**: Drazic, A., Myklebust, L.M., Arnesen, T., et al.

**摘要**: 通过果蝇模型和NAA60抗体的免疫荧光分析,研究发现NAA60通过乙酰化特定底物调控氧化应激反应,缺失NAA60会导致活性氧(ROS)积累,影响细胞存活。抗体实验揭示了其在生殖细胞中的高表达。

3. **文献名称**: *Prognostic and functional role of NAA60 in breast cancer through regulation of mitochondrial metabolism*

**作者**: Li, X., Wang, Y., Zhang, Q., et al.

**摘要**: 该研究利用NAA60抗体进行免疫组化分析,发现NAA60在乳腺癌组织中高表达且与不良预后相关。机制研究表明,NAA60通过乙酰化线粒体相关蛋白增强癌细胞代谢,促进肿瘤生长和转移。

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**备注**:上述文献为示例,实际引用时需核对具体论文信息。若需真实文献,建议在PubMed或Web of Science中以“NAA60 antibody”或“HAT4 acetyltransferase”为关键词检索近期研究。

       

背景信息

The NAA60 antibody is designed to target N-alpha-acetyltransferase 60 (NAA60), also known as HAT4. a member of the N-terminal acetyltransferase (NAT) family. NAA60 is unique among NATs as it localizes to the Golgi apparatus and late endosomes, where it catalyzes the acetylation of the N-termini of transmembrane proteins. This enzyme plays a critical role in maintaining membrane integrity, vesicle trafficking, and cellular signaling by acetylating lysosomal and cell surface proteins. Its substrate specificity includes proteins involved in endocytosis, adhesion, and membrane organization, linking NAA60 to processes like cancer progression and viral entry.

Antibodies against NAA60 are essential tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate NAA60's role in physiological and pathological contexts. Research has shown that NAA60 is overexpressed in certain cancers, including melanoma and breast cancer, where it may promote tumor growth and metastasis by modulating membrane protein stability. Additionally, NAA60 knockdown studies reveal its importance in cell viability, highlighting its potential as a therapeutic target. The NAA60 antibody thus serves as a key reagent in exploring acetylome dynamics and developing targeted therapies for diseases associated with dysregulated membrane biology.

       
关键字: NAA60抗体;NAA60;NAA60 Antibody;

公司简介

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成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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