The UBE2W antibody is a research tool designed to detect and study UBE2W (Ubiquitin-conjugating enzyme E2 W), a member of the E2 ubiquitin-conjugating enzyme family. UBE2W plays a critical role in the ubiquitin-proteasome system, mediating the transfer of ubiquitin to substrate proteins, often in collaboration with E3 ubiquitin ligases. Unlike many E2 enzymes, UBE2W uniquely catalyzes N-terminal ubiquitination, a non-canonical mechanism that tags substrate proteins for degradation or modulates their functional states. This enzyme is implicated in diverse cellular processes, including protein quality control, DNA repair, and regulation of signaling pathways.
UBE2W antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate UBE2W expression, localization, and interactions. Researchers employ these antibodies to explore UBE2W's involvement in diseases such as cancer and neurodegenerative disorders, where dysregulated ubiquitination is common. Additionally, UBE2W antibodies aid in studying its enzymatic activity, substrate specificity, and regulatory mechanisms, offering insights into potential therapeutic targets. Validated for specificity and sensitivity, these antibodies are essential for advancing understanding of ubiquitination dynamics and their pathological implications.