ASXL2抗体,Rabbit Polyclonal ASXL2 Antibody
  • ASXL2抗体,Rabbit Polyclonal ASXL2 Antibody
  • ASXL2抗体,Rabbit Polyclonal ASXL2 Antibody
  • ASXL2抗体,Rabbit Polyclonal ASXL2 Antibody

ASXL2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
QQ交谈 微信洽谈

产品详情

中文名称:ASXL2抗体英文名称:Rabbit Polyclonal ASXL2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4750 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ASXL2
2025-05-20 ASXL2抗体 Rabbit Polyclonal ASXL2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4750 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesASXH2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human ASXL2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09336(ASXL2 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09336(ASXL2 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于ASXL2抗体的模拟参考文献示例(注:实际文献需通过学术数据库查询):

1. **文献名称**:*ASXL2 mutations promote myeloid transformation through loss of PRC2-mediated gene repression*

**作者**:Wang C. et al.

**摘要**:研究利用ASXL2抗体进行免疫沉淀和ChIP-seq分析,发现ASXL2突变通过破坏PRC2复合体的表观遗传调控功能,促进骨髓增生异常综合征向白血病转化。

2. **文献名称**:*ASXL2 interacts with cohesin to maintain chromatin integrity in hematopoietic stem cells*

**作者**:Li Z. et al.

**摘要**:通过ASXL2抗体的Western blot和免疫荧光实验,揭示ASXL2与黏连蛋白复合体协同维持造血干细胞染色质稳定性,缺失导致基因组不稳定性。

3. **文献名称**:*Development and validation of a specific ASXL2 antibody for immunohistochemical analysis in solid tumors*

**作者**:Zhang Y. et al.

**摘要**:报道一种高特异性ASXL2抗体的开发,并验证其在乳腺癌和肺癌组织中的免疫组化应用,发现ASXL2表达与患者预后相关。

4. **文献名称**:*ASXL2 regulates lipid metabolism via PPARγ signaling in adipocytes*

**作者**:Kim H. et al.

**摘要**:利用ASXL2抗体敲低实验,证明ASXL2通过调控PPARγ通路影响脂肪细胞分化及脂质代谢,为代谢性疾病提供新机制。

**建议**:通过PubMed或Google Scholar搜索“ASXL2 antibody”或“ASXL2 function”获取最新文献,关注其表观遗传调控及疾病机制研究。

       

背景信息

The ASXL2 antibody is a research tool used to detect and study the Additional Sex Combs-Like 2 (ASXL2) protein, a member of the ASXL family of chromatin-binding proteins. ASXL proteins (ASXL1-3) play roles in epigenetic regulation by modulating chromatin structure and gene expression through interactions with polycomb repressive complexes (PRC) and other transcriptional regulators. ASXL2. specifically, is involved in deubiquitination processes via its partnership with BAP1 (BRCA1-associated protein 1), influencing histone H2A ubiquitination and transcriptional activation or repression.

ASXL2 is implicated in normal hematopoiesis, embryonic development, and stem cell maintenance. Dysregulation or mutations in ASXL2 have been linked to cancers, including acute myeloid leukemia (AML), though its role is less characterized compared to ASXL1. ASXL2 antibodies are critical for investigating its expression patterns, subcellular localization, and functional interactions in both physiological and pathological contexts. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein levels in cell lines or tissues. Researchers also utilize ASXL2 antibodies to explore its involvement in disease mechanisms, such as aberrant chromatin remodeling in malignancies. However, challenges remain in ensuring antibody specificity due to structural similarities among ASXL family members. Validation using knockout controls or siRNA knockdown is essential for reliable results. Ongoing studies aim to clarify ASXL2's dual roles as a tumor suppressor or oncogene, depending on cellular context.

       
关键字: ASXL2抗体;ASXL2;ASXL2 Antibody;

公司简介

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成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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