The GPANK1 (G Patch Domain Containing Kinase 1) antibody is a research tool designed to detect and study the GPANK1 protein, a member of the homeodomain-interacting protein kinase (HIPK) family. GPANK1. also known as HIPK3. is a serine/threonine kinase implicated in regulating transcription, cell proliferation, apoptosis, and DNA damage response. It interacts with transcription factors, including homeodomain proteins, to modulate gene expression in signaling pathways such as Wnt, TGF-β, and p53. Dysregulation of GPANK1 has been linked to cancers, neurodegenerative disorders, and cardiovascular diseases, highlighting its role in cellular homeostasis and disease pathogenesis.
The GPANK1 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to analyze protein expression, localization, and post-translational modifications in tissues or cell lines. Researchers employ it to explore GPANK1's involvement in tumor progression, neuronal survival, or stress responses, often correlating its expression levels with clinical outcomes. Commercial antibodies are typically validated for specificity and sensitivity, though variability may exist depending on epitope regions or experimental conditions. Ongoing studies aim to clarify GPANK1's mechanistic roles and therapeutic potential, making this antibody a critical reagent for both basic and translational research.