The CORO2B antibody targets Coronin 2B (also known as IR10 or Clipin-B), a member of the coronin protein family involved in regulating cytoskeletal dynamics, particularly actin filament organization. Coronins are evolutionarily conserved and play roles in cell migration, vesicle trafficking, and immune responses. CORO2B is expressed in various tissues, including immune cells, and interacts with proteins like Cofilin and Arp2/3 to modulate actin remodeling. Structurally, it contains WD40 repeats and a coiled-coil domain, facilitating protein-protein interactions.
Research on CORO2B has linked it to diseases such as cancer, metabolic disorders, and viral infections. For instance, it may influence cancer cell invasion by promoting actin-based protrusions or regulate lipid metabolism through interactions with transcription factors like C/EBPβ. CORO2B antibodies are essential tools for studying these mechanisms, enabling detection of protein expression, localization, and functional roles via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent studies also explore its potential as a biomarker or therapeutic target, particularly in contexts where cytoskeletal dysregulation drives pathology. However, its precise molecular pathways and disease-specific contributions remain under investigation, highlighting the need for further research using CORO2B-targeted reagents.