DCAF10抗体,Rabbit Polyclonal DCAF10 Antibody
  • DCAF10抗体,Rabbit Polyclonal DCAF10 Antibody
  • DCAF10抗体,Rabbit Polyclonal DCAF10 Antibody
  • DCAF10抗体,Rabbit Polyclonal DCAF10 Antibody

DCAF10抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
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产品详情

中文名称:DCAF10抗体英文名称:Rabbit Polyclonal DCAF10 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5253 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DCAF10
2025-05-20 DCAF10抗体 Rabbit Polyclonal DCAF10 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5253 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesWDR32
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human DCAF10
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10057(DCAF10 Antibody) at dilution 1/130. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10057(DCAF10 Antibody) at dilution 1/130. (Original magnification: ×200)    


           

参考文献

以下是关于DCAF10抗体的3篇参考文献(内容基于模拟生成,非真实文献):

1. **文献名称**:*DCAF10 as a substrate receptor for CUL4-DDB1 ubiquitin ligase: Antibody development and functional characterization*

**作者**:Smith J, et al.

**摘要**:该研究开发了针对DCAF10蛋白的高特异性多克隆抗体,验证了其在Western blot和免疫沉淀实验中的应用,并揭示DCAF10通过CUL4-DDB1复合物调控底物泛素化降解的分子机制。

2. **文献名称**:*DCAF10 antibody-based profiling reveals tissue-specific expression patterns in cancer*

**作者**:Li X, et al.

**摘要**:利用商业化DCAF10抗体进行免疫组化分析,发现DCAF10在肺癌和结直肠癌组织中表达显著上调,且与患者预后不良相关,提示其可能作为癌症生物标志物。

3. **文献名称**:*Structural insights into DCAF10 interaction with viral proteins using cryo-EM*

**作者**:Wang Y, et al.

**摘要**:通过冷冻电镜解析DCAF10与病毒蛋白的互作结构,研究中采用特异性抗体纯化内源性DCAF10复合物,证实其在宿主抗病毒反应中的调控作用。

4. **文献名称**:*DCAF10 knockdown via antibody-mediated targeting inhibits proliferation in hepatocellular carcinoma*

**作者**:Chen R, et al.

**摘要**:开发了靶向DCAF10的功能阻断性单克隆抗体,体外实验表明其可抑制肝癌细胞增殖,为靶向泛素化通路的治疗策略提供依据。

(注:以上文献为示例,实际研究中请通过PubMed或专业数据库检索真实发表文献。)

       

背景信息

The DCAF10 (DDB1- and CUL4-associated factor 10) antibody is a research tool used to study the DCAF10 protein, a member of the WD40 repeat-containing DCAF family. DCAF10 serves as a substrate receptor within the CUL4-DDB1 E3 ubiquitin ligase complex (CRL4), which plays a critical role in ubiquitination-mediated protein degradation. This protein is involved in recruiting specific substrates for polyubiquitination, marking them for proteasomal destruction. DCAF10's interactions are linked to cellular processes such as DNA repair, cell cycle regulation, and epigenetic modulation, though its exact biological functions remain under investigation.

Antibodies targeting DCAF10 enable researchers to detect, quantify, or localize the protein in various experimental models (e.g., Western blot, immunofluorescence, IP). They are essential for exploring DCAF10's role in diseases, particularly cancer, where dysregulation of ubiquitin-proteasome pathways is common. Recent studies suggest DCAF10 may influence oncogenic signaling or drug resistance, making it a potential therapeutic target. However, detailed mechanistic insights and clinical relevance require further validation. Commercial DCAF10 antibodies are typically validated for specificity and affinity, though performance may vary across applications. Ongoing research aims to clarify its interactome and regulatory networks in cellular homeostasis and pathology.

       
关键字: DCAF10抗体;DCAF10;DCAF10 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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