CLEC6A抗体;CLEC6A Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11709(CLEC6A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

CLEC6A (C-type lectin domain family 6 member A), also known as Dectin-2. is a transmembrane protein belonging to the C-type lectin receptor (CLR) family. It is primarily expressed on myeloid cells, such as dendritic cells and macrophages, and functions as a pattern recognition receptor (PRR) involved in innate immune responses. CLEC6A recognizes carbohydrate structures, particularly α-mannans found on fungal cell walls (e.g., Candida albicans and Malassezia species), and collaborates with other receptors like Dectin-1 to initiate immune signaling. Upon ligand binding, CLEC6A triggers intracellular signaling through the FcRγ adaptor protein, activating Syk kinase and downstream pathways (e.g., NF-κB) to promote cytokine production, phagocytosis, and Th17-mediated adaptive immunity.

CLEC6A antibodies are essential tools for studying its expression, ligand interactions, and role in antifungal defense, autoimmune disorders, or cancer. Monoclonal antibodies targeting CLEC6A have been developed for diagnostic applications (e.g., detecting receptor distribution via flow cytometry or immunohistochemistry) and therapeutic exploration, such as modulating immune responses in fungal infections or allergy. Recent studies also highlight its potential as a biomarker or target in inflammatory diseases. Research using CLEC6A antibodies continues to unravel its dual role in host protection and immune dysregulation, emphasizing its relevance in immunology and translational medicine.